Detailed information for compound 1177838

Basic information

Technical information
  • TDR Targets ID: 1177838
  • Name: 372151-71-8
  • MW: 1755.63 | Formula: C80H106Cl2N11O27P
  • H donors: 23 H acceptors: 21 LogP: -2.12 Rotable bonds: 31
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCCCNCCN[C@@]1(C)C[C@H](O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]([C@@H](c4ccc(O3)c(Cl)c4)O)NC(=O)[C@@H](CC(C)C)NC)c3ccc(c(c3)c3c([C@H](NC2=O)C(=O)O)cc(c(c3O)CNCP(=O)(O)O)O)O)O[C@H]([C@H]1O)C
  • InChi: 1S/C80H106Cl2N11O27P/c1-7-8-9-10-11-12-13-14-21-85-22-23-87-80(5)32-57(115-37(4)71(80)103)119-70-68(102)67(101)55(34-94)118-79(70)120-69-53-28-41-29-54(69)117-52-20-17-40(27-46(52)82)65(99)63-77(109)91-61(78(110)111)43-30-50(96)44(33-86-35-121(112,113)114)66(100)58(43)42-25-38(15-18-49(42)95)59(74(106)93-63)90-75(107)60(41)89-73(105)48(31-56(83)97)88-76(108)62(92-72(104)47(84-6)24-36(2)3)64(98)39-16-19-51(116-53)45(81)26-39/h15-20,25-30,36-37,47-48,55,57,59-65,67-68,70-71,79,84-87,94-96,98-103H,7-14,21-24,31-35H2,1-6H3,(H2,83,97)(H,88,108)(H,89,105)(H,90,107)(H,91,109)(H,92,104)(H,93,106)(H,110,111)(H2,112,113,114)/t37-,47+,48-,55+,57-,59+,60+,61-,62+,63-,64+,65+,67+,68-,70+,71+,79-,80-/m0/s1
  • InChiKey: ONUMZHGUFYIKPM-MXNFEBESSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Telavancin
  • Telavancin [INN]
  • Vancomycin, N3''-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Plasmodium falciparum cyclin 0.0175 0.0758 0.55
Echinococcus multilocularis cyclin b3 0.0175 0.0758 0.0758
Echinococcus granulosus G1:S specific cyclin D1 0.0042 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0074 0.0192 0.0428
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0228 0.0228
Schistosoma mansoni cyclins 0.0175 0.0758 0.1685
Mycobacterium tuberculosis Probable reductase 0.0253 0.1198 0.8342
Onchocerca volvulus 0.008 0.0228 0.1294
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0042 0.0013 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0014 0.0014
Loa Loa (eye worm) cyclin domain-containing protein 0.0539 0.2811 0.6249
Trypanosoma cruzi cdc2-related kinase 3 0.0283 0.1368 0.817
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Schistosoma mansoni adenoreceptor 0.008 0.0228 0.0506
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0228 0.0506
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0228 0.0228
Echinococcus granulosus serotonin receptor 0.008 0.0228 0.0228
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0281 0.1356 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0228 0.0228
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus cyclin dependent kinase 5 0.0283 0.1368 0.1368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0839 0.4498 0.4498
Echinococcus granulosus somatostatin receptor 0.008 0.0228 0.0228
Echinococcus granulosus cyclin b3 0.0175 0.0758 0.0758
Trichomonas vaginalis cyclin B, putative 0.0042 0.0013 0.0075
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0124 0.0124
Echinococcus granulosus neuropeptide receptor 0.0145 0.0592 0.0592
Echinococcus multilocularis serotonin receptor 0.008 0.0228 0.0228
Brugia malayi cyclin fold protein 1 variant b 0.0042 0.0013 0.0045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0111 0.0399 0.0399
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0228 0.0506
Giardia lamblia Cyclin A 0.0175 0.0758 0.4486
Schistosoma mansoni cyclin B3 0.0539 0.2811 0.6249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0013 0.0075
Trypanosoma cruzi cruzipain precursor, putative 0.0076 0.0204 0.122
Echinococcus granulosus cyclin y 0.0042 0.0013 0.0013
Echinococcus granulosus GPCR family 2 0.0042 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclin B3 1 0.0175 0.0758 0.0758
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0032
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trypanosoma cruzi cyclin, putative 0.0337 0.1674 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0228 0.0809
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Trichomonas vaginalis cyclin A, putative 0.0337 0.1674 1
Trypanosoma cruzi cdc2-related kinase 1 0.0283 0.1368 0.817
Brugia malayi Serotonin receptor 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Brugia malayi Cyclin C 0.0042 0.0013 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0228 0.0506
Plasmodium falciparum glutathione reductase 0.0111 0.0399 0.2851
Schistosoma mansoni myosin xvIII 0.008 0.0228 0.0506
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0195 0.087 0.1935
Entamoeba histolytica cyclin family protein 0.0175 0.0758 0.4527
Trypanosoma brucei cdc2-related kinase 1 0.0283 0.1368 0.817
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0015 0.0015
Echinococcus granulosus allatostatin A receptor 0.008 0.0228 0.0228
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0042 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Brugia malayi Cyclin, N-terminal domain containing protein 0.0539 0.2811 1
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0018 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0228 0.0506
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0228 0.0228
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.0228 0.0809
Brugia malayi putative neuropeptide receptor 0.008 0.0228 0.0809
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin dependent kinase 1 0.0283 0.1368 0.1368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0042 0.0013 0.0091
Brugia malayi G-protein coupled receptor 0.008 0.0228 0.0809
Echinococcus multilocularis cyclin k 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0228 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei cyclin 3 0.0042 0.0013 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus orexin receptor type 2 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Toxoplasma gondii cyclin dependent kinase binding protein 0.0042 0.0013 0.0091
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0228 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Leishmania major trypanothione reductase 0.0111 0.0399 0.2383
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0015 0.0087
Trypanosoma brucei cdc2-related kinase 3 0.0283 0.1368 0.817
Echinococcus multilocularis cyclin G2 0.0042 0.0013 0.0013
Trichomonas vaginalis cyclin B3, putative 0.0175 0.0758 0.4527
Trichomonas vaginalis cyclin D, putative 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclin y 0.0042 0.0013 0.0013
Echinococcus granulosus tar DNA binding protein 0.0062 0.0124 0.0124
Schistosoma mansoni alpha-glucosidase 0.0167 0.0718 0.1596
Loa Loa (eye worm) cyclin C 0.0042 0.0013 0.0028
Brugia malayi Thioredoxin reductase 0.0111 0.0399 0.1419
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0015 0.0015
Echinococcus multilocularis G1:S specific cyclin D1 0.0042 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.087 0.087
Echinococcus granulosus cyclin B3 1 0.0175 0.0758 0.0758
Echinococcus multilocularis neuropeptide receptor 0.0145 0.0592 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0018 0.011
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.0402 0.2036 0.4527
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0228 0.0506
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis cyclin B, putative 0.0042 0.0013 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0134 0.0528 0.1175
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0283 0.1368 0.817
Trichomonas vaginalis cyclins, putative 0.0205 0.0929 0.5548
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0192 0.0192
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0228 0.0228
Echinococcus multilocularis Cyclin L1 0.0042 0.0013 0.0013
Brugia malayi Dopamine receptor 0.008 0.0228 0.0809
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0042 0.0013 0.0013
Entamoeba histolytica cell division protein kinase 2, putative 0.0283 0.1368 0.817
Loa Loa (eye worm) glutathione reductase 0.0111 0.0399 0.0887
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei trypanothione reductase 0.0111 0.0399 0.2383
Giardia lamblia Hypothetical protein 0.0175 0.0758 0.4486
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Plasmodium falciparum protein kinase 5 0.0283 0.1368 1
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0013 0.0075
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0228 0.0228
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0228 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0015 0.0087
Brugia malayi Serotonin receptor 0.008 0.0228 0.0809
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0228 0.0809
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0042 0.0013 0.0013
Trypanosoma cruzi cdc2-related kinase 3 0.0283 0.1368 0.817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0014 0.0014
Schistosoma mansoni Cyclin fold protein 0.0042 0.0013 0.0028
Loa Loa (eye worm) thioredoxin reductase 0.0111 0.0399 0.0887
Loa Loa (eye worm) hypothetical protein 0.0134 0.0528 0.1175
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0337 0.1674 0.5956
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) CYL-1 protein 0.0042 0.0013 0.0028
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0539 0.2811 0.2811
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Echinococcus multilocularis GPCR, family 2 0.0042 0.0014 0.0014
Echinococcus multilocularis G protein coupled receptor 139 0.0145 0.0592 0.0592
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Echinococcus multilocularis sex peptide receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0112 0.0672
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0228 0.0228
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0228 0.0228
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0042 0.0013 0.0028
Trichomonas vaginalis cyclins, putative 0.0042 0.0013 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0228 0.0506
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0014 0.0014
Echinococcus multilocularis somatostatin receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0337 0.1674 0.3722
Echinococcus granulosus g-protein coupled receptor 0.008 0.0228 0.0228
Echinococcus multilocularis fmrfamide receptor 0.008 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0042 0.0013 0.0028
Schistosoma mansoni cyclin d 0.0042 0.0013 0.0028
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0228 0.0228
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0228 0.0506
Schistosoma mansoni cyclin G 0.0042 0.0013 0.0028
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0228 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0018 0.011
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus granulosus thioredoxin glutathione reductase 0.0111 0.0399 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1368 0.3041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Plasmodium vivax glutathione reductase, putative 0.0111 0.0399 0.2851
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Onchocerca volvulus 0.008 0.0228 0.1294
Brugia malayi G protein-coupled receptor 0.008 0.0228 0.0809
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis cyclin dependent kinase 1 0.0283 0.1368 0.1368
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0228 0.0228
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0228 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Plasmodium vivax protein kinase Crk2 0.0283 0.1368 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0283 0.1368 0.1368
Echinococcus granulosus cyclin B 0.0337 0.1674 0.1674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Loa Loa (eye worm) hypothetical protein 0.0402 0.2036 0.4527
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Toxoplasma gondii hypothetical protein 0.0132 0.0521 0.3808
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0014 0.0048
Schistosoma mansoni cyclin G2 0.0042 0.0013 0.0028
Schistosoma mansoni histamine h1 receptor 0.008 0.0228 0.0506
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus cyclin k 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0337 0.1674 0.3722
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0018 0.011
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0228 0.0506
Echinococcus granulosus sex peptide receptor 0.008 0.0228 0.0228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.0074 0.0192 0.0685
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0228 0.0228
Trichomonas vaginalis cyclins, putative 0.0175 0.0758 0.4527
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0015 0.0015
Giardia lamblia Kinase, CMGC CDK 0.0283 0.1368 0.8156
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0015 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0758 0.4527
Trichomonas vaginalis cyclin D, putative 0.0175 0.0758 0.4527
Brugia malayi AKH receptor 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Brugia malayi latrophilin 2 splice variant baaae 0.0091 0.029 0.1032
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0283 0.1368 0.3041
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0015 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0042 0.0013 0.0075
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0228 0.0506
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Plasmodium vivax thioredoxin reductase, putative 0.0111 0.0399 0.2851
Schistosoma mansoni hypothetical protein 0.0091 0.029 0.0645
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0283 0.1368 0.3041
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0228 0.0228
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0228 0.0228
Brugia malayi neuropeptide F receptor 0.008 0.0228 0.0809
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Onchocerca volvulus 0.008 0.0228 0.1294
Loa Loa (eye worm) hypothetical protein 0.028 0.1351 0.3003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0228 0.1294
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0253 0.1198 0.8342
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis fmrfamide receptor 0.008 0.0228 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1174 0.8095
Giardia lamblia Kinase, CMGC CDK 0.0283 0.1368 0.8156
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0228 0.0228
Echinococcus granulosus cyclin dependent kinase 0.0283 0.1368 0.1368
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Echinococcus granulosus fmrfamide receptor 0.008 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Trichomonas vaginalis cyclins, putative 0.0042 0.0013 0.0075
Trypanosoma cruzi cyclin, putative 0.0337 0.1674 1
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0228 0.0228
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0228 0.0228
Onchocerca volvulus 0.008 0.0228 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Leishmania major cyclin 0.0337 0.1674 1
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Brugia malayi RE15519p 0.008 0.0228 0.0809
Echinococcus granulosus cyclin A3 4 0.0042 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Brugia malayi cell division control protein 2 homolog 0.0283 0.1368 0.4866
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.0228 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Brugia malayi G-protein coupled receptor 0.008 0.0228 0.0809
Brugia malayi Cyclin, N-terminal domain containing protein 0.0337 0.1674 0.5956
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1368 0.3041
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Schistosoma mansoni cyclin B 0.0337 0.1674 0.3722
Brugia malayi Glycosyl hydrolases family 31 protein 0.0195 0.087 0.3097
Onchocerca volvulus 0.008 0.0228 0.1294
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0253 0.1198 0.8342
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0228 0.0228
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0283 0.1368 0.817
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0042 0.0013 0.0028
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0228 0.0228
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.0228 0.0228
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin A, putative 0.0042 0.0013 0.0075
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0124 0.0443
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0281 0.1356 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin A3 4 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Trypanosoma cruzi CYC2-like cyclin, putative 0.0337 0.1674 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Toxoplasma gondii hypothetical protein 0.0042 0.0013 0.0091
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Trypanosoma cruzi cyclin 6, putative 0.0337 0.1674 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0134 0.0528 0.1879
Brugia malayi RNA binding protein 0.0062 0.0124 0.0443
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0228 0.0228
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0228 0.0809
Echinococcus multilocularis cyclin 0.0042 0.0013 0.0013
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0018 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0228 0.0506
Echinococcus multilocularis orexin receptor type 2 0.008 0.0228 0.0228
Echinococcus multilocularis cyclin dependent kinase 5 0.0283 0.1368 0.1368
Mycobacterium tuberculosis Probable oxidoreductase 0.0281 0.1356 1
Trichomonas vaginalis cyclin B, putative 0.0175 0.0758 0.4527
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.167 0.9174 0.9174
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0042 0.0013 0.0013
Echinococcus granulosus cyclin G2 0.0042 0.0013 0.0013
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.0228 0.0228
Trypanosoma brucei mitotic cyclin 6 0.0337 0.1674 1
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Brugia malayi glutathione reductase 0.0111 0.0399 0.1419
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0228 0.0228
Echinococcus granulosus neuropeptide receptor 0.008 0.0228 0.0228
Brugia malayi larval opioid receptor 0.008 0.0228 0.0809
Echinococcus granulosus cyclin dependent kinase 1 0.0283 0.1368 0.1368
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0283 0.1368 0.3041
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0042 0.0013 0.0028
Onchocerca volvulus 0.008 0.0228 0.1294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0253 0.1198 0.8342
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptide receptor 0.008 0.0228 0.0228
Echinococcus granulosus hypothetical protein 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0015 0.0032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0253 0.1198 0.8342
Onchocerca volvulus 0.0337 0.1674 1
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Onchocerca volvulus 0.008 0.0228 0.1294
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0283 0.1368 1
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0228 0.0506
Echinococcus granulosus cyclin 0.0042 0.0013 0.0013
Brugia malayi GnHR receptor homolog 0.008 0.0228 0.0809
Onchocerca volvulus 0.0113 0.0409 0.2385
Leishmania major mitotic cyclin, putative 0.0042 0.0013 0.0075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0018 0.011
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Trypanosoma cruzi cyclin 9, putative 0.0042 0.0013 0.0075
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Schistosoma mansoni alpha glucosidase 0.0043 0.0018 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Schistosoma mansoni cyclin k 0.0042 0.0013 0.0028
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Toxoplasma gondii thioredoxin reductase 0.0111 0.0399 0.2917
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclin dependent kinase 0.0283 0.1368 0.1368
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0018 0.011
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0283 0.1368 0.4866
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Echinococcus granulosus Cyclin L1 0.0042 0.0013 0.0013
Brugia malayi sulfakinin receptor protein 0.008 0.0228 0.0809
Brugia malayi hypothetical protein 0.0042 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Entamoeba histolytica cyclin family protein 0.0175 0.0758 0.4527
Entamoeba histolytica cell division protein kinase 2, putative 0.0283 0.1368 0.817
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0539 0.2811 0.2811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Trypanosoma brucei cyclin 9 0.0042 0.0013 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0228 0.0506
Trypanosoma cruzi trypanothione reductase, putative 0.0111 0.0399 0.2383
Echinococcus granulosus cyclin y 0.0042 0.0013 0.0013
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0228 0.0809
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0018 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni neuropeptide receptor 0.0145 0.0592 0.1316
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0228 0.0506
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0839 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.0402 0.2036 0.7244
Brugia malayi TAR-binding protein 0.0062 0.0124 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus granulosus cyclin G2 0.0042 0.0013 0.0013
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0228 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Brugia malayi ORL1-like opioid receptor 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0329 0.1626 0.3615
Trypanosoma brucei mitotic cyclin 0.0042 0.0013 0.0075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0014 0.0048
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0228 0.0506
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0167 0.0997
Schistosoma mansoni cyclin l 0.0042 0.0013 0.0028
Trichomonas vaginalis cyclin D, putative 0.0175 0.0758 0.4527
Toxoplasma gondii cyclin 4, putative 0.0042 0.0013 0.0091
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0228 0.0506
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0042 0.0013 0.0075
Echinococcus granulosus cyclin t1 0.0042 0.0013 0.0013
Leishmania major mitotic cyclin, putative 0.0042 0.0013 0.0075
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0228 0.1294
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis cyclin G2 0.0042 0.0013 0.0013
Echinococcus multilocularis cyclin t1 0.0042 0.0013 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0018 0.0041
Brugia malayi neuropeptide F receptor 0.008 0.0228 0.0809
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0015 0.0015
Brugia malayi Dopamine receptor protein 2 0.008 0.0228 0.0809
Echinococcus multilocularis allatostatin A receptor 0.008 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi Dopamine receptor protein 1 0.008 0.0228 0.0809
Echinococcus multilocularis cyclin y 0.0042 0.0013 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0124 0.0277
Echinococcus multilocularis cyclin B 0.0337 0.1674 0.1674
Entamoeba histolytica cyclin C, putative 0.0042 0.0013 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0228 0.0228
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0337 0.1674 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0018 0.011
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0013 0.0075
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.011
Leishmania major cyclin 9, putative 0.0042 0.0013 0.0075
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0228 0.0506
Plasmodium falciparum thioredoxin reductase 0.0111 0.0399 0.2851
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0228 0.0228
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0015 0.0012
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.0091 0.029 0.0645
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0014 0.003
Entamoeba histolytica cyclin, putative 0.0337 0.1674 1
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0028
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Giardia lamblia G2/mitotic-specific cyclin B 0.0337 0.1674 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0015 0.0015
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0015 0.0087
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0281 0.1356 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0228 0.0506
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Echinococcus granulosus cyclins 0.0042 0.0013 0.0013
Brugia malayi Melatonin receptor type 1A 0.008 0.0228 0.0809
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0013 0.0075
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus granulosus lysosomal alpha glucosidase 0.0195 0.087 0.087
Mycobacterium tuberculosis Probable dehydrogenase 0.0253 0.1198 0.8342
Echinococcus granulosus neuropeptide s receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0228 0.0506
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0015 0.0087
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Echinococcus multilocularis serotonin receptor 0.008 0.0228 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Trypanosoma cruzi cdc2-related kinase 1 0.0283 0.1368 0.817
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni g1/s-specific cyclin C 0.0042 0.0013 0.0028
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0228 0.0228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0134 0.0528 0.1879
Trypanosoma brucei glucosidase, putative 0.0043 0.0018 0.011
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0015 0.0087
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0839 0.4498 1
Brugia malayi follicle stimulating hormone receptor 0.0329 0.1626 0.5785
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0192 0.0428
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0124 0.0277
Schistosoma mansoni alpha-glucosidase 0.0167 0.0718 0.1596
Loa Loa (eye worm) RNA binding protein 0.0062 0.0124 0.0277
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0228 0.0228
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0163 0.0692 0.1538
Brugia malayi hypothetical protein 0.0042 0.0013 0.0045
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0228 0.0506
Entamoeba histolytica cyclin, putative 0.0175 0.0758 0.4527
Loa Loa (eye worm) hypothetical protein 0.0839 0.4498 1

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 90 % Protein binding in human at 7.5 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
Activity (ADMET) = 90 % Protein binding in human at 10 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
Activity (ADMET) = 92 % Protein binding in human plasma ChEMBL. 17620377
AUC (ADMET) = 604 microg.hr/mL AUC in human at 7.5 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
AUC (ADMET) = 785 microg.hr/mL AUC in human at 10 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
AUC (ADMET) = 51 ug.hr/ml AUC (0 to 24 hrs) in human at 10 mg/kg once daily ChEMBL. 17620377
AUC (ADMET) = 785 ug.hr/ml AUC (0 to 24) in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
CL (ADMET) = 13 ml/hr.kg Clearance at steady state in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
Cmax (ADMET) = 5.2 mg/L Cmax in human at 10 mg/kg once daily ChEMBL. 17620377
Cmax (ADMET) = 60 mg/L Cmax in human serum at 7.5 mg/kg ChEMBL. 17620377
Cmax (ADMET) = 89 ug ml-1 Cmax in human at 7.5 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
Cmax (ADMET) = 90 ug ml-1 Cmax in human plasma ChEMBL. 19188393
Cmax (ADMET) = 116 ug ml-1 Cmax in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
Cmin (ADMET) = 6 ug ml-1 Cmin in human at 7.5 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
Cmin (ADMET) = 8.11 ug ml-1 Cmin in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
Cp (ADMET) = 5.1 ug ml-1 Plasma concentration in healthy human undergoing fiber-optic bronchoscopy at 1g, iv twice daily for 3 days measured at 12 hrs after start of infusion by validated liquid chromatography ChEMBL. 17923490
Cp (ADMET) = 7.28 ug ml-1 Plasma concentration in healthy human undergoing fiber-optic bronchoscopy at 10 mg/kg, iv once daily for 3 days measured at 24 hrs after start of infusion by validated liquid chromatography ChEMBL. 17923490
Cp (ADMET) = 22.9 ug ml-1 Plasma concentration in healthy human undergoing fiber-optic bronchoscopy at 10 mg/kg, iv once daily for 3 days measured at 12 hrs after start of infusion by validated liquid chromatography ChEMBL. 17923490
Cp (ADMET) = 96.7 ug ml-1 Plasma concentration in human at 7.5 mg/kg ChEMBL. 17606689
fAUC (ADMET) = 52.3 microg/hr/ml fAUC (0 to 24) in mouse pneumonia model at 40 mg/kg ChEMBL. 17923490
Fu (ADMET) = 7 % Fraction unbound in human plasma ChEMBL. 19188393
MRT (ADMET) = 9.42 hr Mean residence time in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
PB (ADMET) = 90 % Protein binding in human plasma ChEMBL. 17606689
PB (ADMET) >= 90 % Protein binding healthy human serum ChEMBL. 19124659
PB (ADMET) = 95 % Protein binding in mouse plasma at 0.1 to 100 ug/mL by equilibrium dialysis ChEMBL. 17908947
PPB (ADMET) = 90 % Plasma protein binding in human plasma at 750 mg administered as single dose ChEMBL. 18426898
T1/2 (ADMET) = 6.18 hr Terminal half life in human at 7.5 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
T1/2 (ADMET) = 7 hr Half life in human serum at 7.5 mg/kg ChEMBL. 17620377
T1/2 (ADMET) > 7 hr Elimination half life in healthy human at 5 mg/kg, iv ChEMBL. 19124659
T1/2 (ADMET) = 7.41 hr Terminal half life in human at 10 mg/kg, iv administered every 24 hrs ChEMBL. 17485502
T1/2 (ADMET) = 7.41 hr Terminal half life in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
Tmax (ADMET) = 1 hr Tmax in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490
Vdss (ADMET) = 122 ml/kg Volume of distribution at steady state in healthy human at 10 mg/kg, iv once daily for 3 days measured at 24 after start of infusion ChEMBL. 17923490

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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