Detailed information for compound 1185266

Basic information

Technical information
  • TDR Targets ID: 1185266
  • Name: [2-(cyclopropylamino)-2-oxoethyl] 5-methylthi ophene-2-carboxylate
  • MW: 239.291 | Formula: C11H13NO3S
  • H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(s1)C)OCC(=O)NC1CC1
  • InChi: 1S/C11H13NO3S/c1-7-2-5-9(16-7)11(14)15-6-10(13)12-8-3-4-8/h2,5,8H,3-4,6H2,1H3,(H,12,13)
  • InChiKey: DNFPFGWFGWJSLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(cyclopropylamino)-2-oxo-ethyl] 5-methylthiophene-2-carboxylate
  • 5-methyl-2-thiophenecarboxylic acid [2-(cyclopropylamino)-2-oxoethyl] ester
  • 5-methylthiophene-2-carboxylic acid [2-(cyclopropylamino)-2-keto-ethyl] ester
  • ZINC03291645
  • T0512-1290
  • Oprea1_536559
  • Enamine_004558

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.065 0.0746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1466 0.1756
Schistosoma mansoni DNA polymerase eta 0.0022 0.0314 0.0329
Mycobacterium ulcerans hypothetical protein 0.0021 0.0258 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0007
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0076 0.2812 0.3408
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0314 0.0249
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0314 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Mycobacterium tuberculosis Probable integral membrane protein 0.0021 0.0258 0.0237
Loa Loa (eye worm) pyruvate kinase 0.0076 0.2812 0.285
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1466 0.1465
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.4066 0.4976
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0152 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.4335 0.7305
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.8123 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.1508 0.3728
Entamoeba histolytica hypothetical protein 0.0037 0.1004 0.2253
Leishmania major trypanothione reductase 0.0048 0.1508 0.179
Loa Loa (eye worm) pyruvate kinase-PB 0.0053 0.175 0.1758
Plasmodium vivax protease, putative 0.0021 0.0258 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.8123 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.1508 0.5251
Plasmodium falciparum glutathione reductase 0.0048 0.1508 0.5251
Trypanosoma brucei pyruvate kinase 1 0.0076 0.2812 0.7149
Echinococcus granulosus pyruvate kinase 0.0039 0.1104 0.1307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.166 0.1665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0067 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0191 0.8123 1
Schistosoma mansoni hypothetical protein 0.0037 0.1004 0.1184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0314 0.0639
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.1508 0.1808
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0101 0.3934 0.3893
Echinococcus granulosus pyruvate kinase 0.0039 0.1104 0.1307
Toxoplasma gondii hypothetical protein 0.0021 0.0258 0.0237
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0314 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1466 0.1756
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0191 0.8123 1
Brugia malayi hypothetical protein 0.0037 0.1004 0.099
Plasmodium falciparum pyruvate kinase 2 0.0039 0.1104 0.3777
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0314 0.0307
Echinococcus multilocularis dna polymerase eta 0.0022 0.0314 0.0329
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0101 0.3934 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1466 0.1756
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.065 0.0724
Entamoeba histolytica hypothetical protein 0.0037 0.1004 0.2253
Echinococcus granulosus pyruvate kinase 0.0076 0.2812 0.3423
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0152 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.166 0.1665
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0314 0.0639
Mycobacterium tuberculosis Probable reductase 0.0109 0.4335 0.5298
Onchocerca volvulus Pyruvate kinase homolog 0.0076 0.2812 0.2312
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0023 0.0364 0.0332
Giardia lamblia DINP protein human, muc B family 0.0022 0.0314 0.0639
Echinococcus multilocularis pyruvate kinase 0.0076 0.2812 0.3423
Trypanosoma brucei CAAX amino terminal protease, putative 0.0101 0.3934 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.065 0.0746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1466 0.1756
Echinococcus multilocularis pyruvate kinase 0.006 0.2073 0.2507
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0314 0.028
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.1508 0.1509
Leishmania major DNA polymerase eta, putative 0.0022 0.0314 0.0307
Entamoeba histolytica CAAX amino terminal protease family 0.0021 0.0258 0.0281
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0067 0.017
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.1508 0.1808
Schistosoma mansoni hypothetical protein 0.0174 0.7317 0.9002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0191 0.8123 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.1508 0.179
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0152 0.4436
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0152 0.0105
Plasmodium vivax SET domain protein, putative 0.0029 0.065 0.2126
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0152 0.0128
Loa Loa (eye worm) pyruvate kinase 0.0076 0.2812 0.285
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0152 0.0309
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0152 0.0113
Loa Loa (eye worm) hypothetical protein 0.0053 0.175 0.1758
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.028
Loa Loa (eye worm) hypothetical protein 0.0103 0.4066 0.414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1466 0.1756
Brugia malayi Pre-SET motif family protein 0.0029 0.065 0.0626
Treponema pallidum hypothetical protein 0.0021 0.0258 1
Giardia lamblia Hypothetical protein 0.0101 0.3934 1
Echinococcus multilocularis pyruvate kinase 0.0076 0.2812 0.3423
Schistosoma mansoni pyruvate kinase 0.0076 0.2812 0.3423
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0021 0.0258 0.0237
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0048 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0601 0.0684
Brugia malayi Pyruvate kinase, M2 isozyme 0.0076 0.2812 0.285
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Onchocerca volvulus Pyruvate kinase homolog 0.0076 0.2812 0.2312
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.065 0.0746
Echinococcus multilocularis geminin 0.0174 0.7317 0.9002
Schistosoma mansoni pyruvate kinase 0.0039 0.1104 0.1307
Brugia malayi Pyruvate kinase, muscle isozyme 0.0076 0.2812 0.285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1466 0.1756
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0258 0.0237
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.4335 0.5298
Toxoplasma gondii hypothetical protein 0.0021 0.0258 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.1508 0.179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0314 0.0307
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0314 0.0798
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0101 0.3934 0.4801
Trichomonas vaginalis pyruvate kinase, putative 0.0076 0.2812 0.2764
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1004 0.1184
Loa Loa (eye worm) hypothetical protein 0.0029 0.065 0.0626
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0152 0.0219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1466 0.1465
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.065 0.0746
Echinococcus granulosus dna polymerase eta 0.0022 0.0314 0.0329
Loa Loa (eye worm) pyruvate kinase 0.0076 0.2812 0.285
Toxoplasma gondii exonuclease III APE 0.0018 0.0152 0.0105
Giardia lamblia Pyruvate kinase 0.0039 0.1104 0.2682
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0067 0.0026
Echinococcus granulosus pyruvate kinase 0.0039 0.1104 0.1307
Brugia malayi Trypsin family protein 0.0103 0.4066 0.414
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0314 0.0798
Entamoeba histolytica pyruvate kinase, putative 0.0053 0.175 0.4226
Entamoeba histolytica CAAX prenyl protease family 0.0101 0.3934 1
Brugia malayi Thioredoxin reductase 0.0048 0.1508 0.1509
Toxoplasma gondii CAAX amino terminal protease family protein 0.0021 0.0258 0.0237
Echinococcus granulosus dna polymerase kappa 0.0022 0.0314 0.0329
Trypanosoma cruzi pyruvate kinase 2, putative 0.0076 0.2812 0.7099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0048 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0067 0.017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0152 0.0105
Leishmania major pyruvate kinase 0.0076 0.2812 0.3408
Mycobacterium ulcerans pyruvate kinase 0.0076 0.2812 0.3408
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0314 0.0329
Plasmodium vivax pyruvate kinase 2, putative 0.0039 0.1104 0.3777
Entamoeba histolytica hypothetical protein 0.0037 0.1004 0.2253
Plasmodium falciparum protease, putative 0.0021 0.0258 0.0697
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0152 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1466 0.1756
Echinococcus multilocularis pyruvate kinase 0.0039 0.1104 0.1307
Loa Loa (eye worm) hypothetical protein 0.0103 0.4066 0.414
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1004 0.1184
Loa Loa (eye worm) hypothetical protein 0.0035 0.0914 0.0897
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.8123 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0048 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0314 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.065 0.0746
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0314 0.0798
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1004 0.1184
Trypanosoma brucei pyruvate kinase 1, putative 0.0076 0.2812 0.7149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0152 0.0105
Onchocerca volvulus Pyruvate kinase homolog 0.0076 0.2812 0.2312
Toxoplasma gondii pyruvate kinase PyK1 0.0076 0.2812 0.3408
Loa Loa (eye worm) hypothetical protein 0.0076 0.2812 0.285
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0067 0.017
Giardia lamblia Pyruvate kinase 0.0076 0.2812 0.7099
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0101 0.3934 0.4813
Trichomonas vaginalis pyruvate kinase, putative 0.0076 0.2812 0.2764
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.4335 0.5298
Trypanosoma brucei unspecified product 0.0022 0.0314 0.0798
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0152 0.0219
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.4896 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0314 0.0307
Echinococcus multilocularis CAAX prenyl protease 2 0.0101 0.3934 0.4813
Plasmodium vivax pyruvate kinase, putative 0.0076 0.2812 1
Brugia malayi follicle stimulating hormone receptor 0.0227 0.9762 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0314 0.0798
Leishmania major pyruvate kinase 0.0076 0.2812 0.3408
Brugia malayi CAAX amino terminal protease family protein 0.0101 0.3934 0.4004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0152 0.0309
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0152 0.0128
Loa Loa (eye worm) hypothetical protein 0.0101 0.3934 0.4004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.4896 0.5995
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.4896 0.5995
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.065 0.0746
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.4896 0.5995
Plasmodium falciparum thioredoxin reductase 0.0048 0.1508 0.5251
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Schistosoma mansoni hypothetical protein 0.0035 0.0914 0.1072
Plasmodium falciparum pyruvate kinase 0.0076 0.2812 1
Onchocerca volvulus 0.0097 0.3755 0.3321
Mycobacterium ulcerans integral membrane protein 0.0021 0.0258 0.0237
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.065 0.0746
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.8123 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.4335 0.5298
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0067 0.0023
Schistosoma mansoni hypothetical protein 0.0174 0.7317 0.9002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0314 0.0639
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0314 0.0307
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0314 0.0307
Schistosoma mansoni pyruvate kinase 0.0076 0.2812 0.3423
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0152 0.0386
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.4335 0.5298
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0314 0.0329
Plasmodium vivax glutathione reductase, putative 0.0048 0.1508 0.5251
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0067 0.0023
Mycobacterium ulcerans hypothetical protein 0.0021 0.0258 0.0237
Entamoeba histolytica CAAX amino terminal protease family 0.0021 0.0258 0.0281
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0152 0.0085
Chlamydia trachomatis hypothetical protein 0.0021 0.0258 0.0697
Entamoeba histolytica hypothetical protein 0.0037 0.1004 0.2253
Echinococcus multilocularis pyruvate kinase 0.0039 0.1104 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0314 0.0798
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0314 0.0329
Schistosoma mansoni ap endonuclease 0.0018 0.0152 0.0128
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.9762 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.8123 1
Brugia malayi Pre-SET motif family protein 0.0204 0.8701 0.8909
Echinococcus granulosus pyruvate kinase 0.0076 0.2812 0.3423
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0152 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0314 0.0639
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0021 0.0258 0.0237
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0314 0.0307
Toxoplasma gondii pyruvate kinase PyKII 0.0039 0.1104 0.1287
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0914 0.0897
Echinococcus multilocularis pyruvate kinase 0.0039 0.1104 0.1307
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0191 0.8123 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.1508 0.1509
Schistosoma mansoni ap endonuclease 0.0018 0.0152 0.0128
Echinococcus granulosus geminin 0.0174 0.7317 0.9002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0314 0.0639
Toxoplasma gondii aldehyde dehydrogenase 0.0191 0.8123 1
Echinococcus granulosus CAAX prenyl protease 2 0.0101 0.3934 0.4813
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0101 0.3934 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.166 0.1665
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0314 0.0429
Trypanosoma cruzi pyruvate kinase 2, putative 0.0076 0.2812 0.7099
Brugia malayi glutathione reductase 0.0048 0.1508 0.1509
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0067 0.017
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0314 0.0249
Chlamydia trachomatis pyruvate kinase 0.0076 0.2812 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.166 0.1665
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0314 0.028
Onchocerca volvulus 0.0103 0.4066 0.3653
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.4335 0.5298
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.4066 0.4976
Trypanosoma brucei trypanothione reductase 0.0048 0.1508 0.3834
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.8701 0.8909
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0101 0.3934 0.4813

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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