Detailed information for compound 1192256

Basic information

Technical information
  • TDR Targets ID: 1192256
  • Name: (E)-4-oxo-4-[4-(1-propylbenzimidazol-2-yl)pip erazin-1-yl]but-2-enoic acid
  • MW: 342.392 | Formula: C18H22N4O3
  • H donors: 1 H acceptors: 4 LogP: 1.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(nc2c1cccc2)N1CCN(CC1)C(=O)/C=C/C(=O)O
  • InChi: 1S/C18H22N4O3/c1-2-9-22-15-6-4-3-5-14(15)19-18(22)21-12-10-20(11-13-21)16(23)7-8-17(24)25/h3-8H,2,9-13H2,1H3,(H,24,25)/b8-7+
  • InChiKey: CSAVWLUZXKMCBZ-BQYQJAHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-oxo-4-[4-(1-propylbenzimidazol-2-yl)piperazin-1-yl]but-2-enoic acid
  • (E)-4-oxo-4-[4-(1-propyl-2-benzimidazolyl)-1-piperazinyl]but-2-enoic acid
  • 4-oxo-4-[4-(1-propyl-2-benzimidazolyl)-1-piperazinyl]but-2-enoic acid
  • 4-keto-4-[4-(1-propylbenzimidazol-2-yl)piperazin-1-yl]but-2-enoic acid
  • (E)-4-keto-4-[4-(1-propylbenzimidazol-2-yl)piperazin-1-yl]but-2-enoic acid
  • ASN 06355133

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.1321 0.1464
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0673 0.124
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0561 0.0022
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0178 0.4628 0.4566
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0257 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0127 0.0029
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.2445 0.5284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0828 0.0867
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0257 0.0318
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0176 0.0138
Schistosoma mansoni inositol monophosphatase 0.0041 0.0673 0.0679
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0193
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0673 0.124
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0178 0.4628 0.4566
Chlamydia trachomatis hypothetical protein 0.0037 0.0561 0.5
Brugia malayi Inositol-1 0.0041 0.0673 0.1455
Toxoplasma gondii hypothetical protein 0.0037 0.0561 0.3501
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Entamoeba histolytica hypothetical protein 0.0036 0.0545 0.0956
Loa Loa (eye worm) inositol-1 0.0041 0.0673 0.0679
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0266
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0257 0.3211
Schistosoma mansoni importin beta-1 0.0029 0.0333 0.0266
Schistosoma mansoni voltage-gated potassium channel 0.0171 0.4418 0.5221
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1321 0.1464
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.2445 0.5165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1302 0.1202
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0127 0.0029
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0673 0.124
Brugia malayi Importin beta-1 subunit 0.0029 0.0333 0.0719
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0257 0.0318
Toxoplasma gondii CAAX metallo endopeptidase 0.0066 0.139 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.2445 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0257 0.0556
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0176 0.0138
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0333 0.0221
Echinococcus multilocularis potassium voltage gated channel protein 0.0171 0.4418 0.5221
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0673 0.0566
Plasmodium falciparum protease, putative 0.0037 0.0561 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0828 0.0867
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0828 0.0867
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0178 0.4628 1
Schistosoma mansoni voltage-gated potassium channel 0.0171 0.4418 0.5221
Schistosoma mansoni kinase 0.0052 0.0999 0.1073
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0979 0.0875
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0178 0.4628 0.4566
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0257 0.0145
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1321 0.1699
Onchocerca volvulus 0.0091 0.2124 0.3468
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0333 0.0221
Brugia malayi Peptidase family M48 containing protein 0.0066 0.139 0.3005
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0257 0.0174
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0673 0.0566
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.2445 0.2828
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0551 0.5
Giardia lamblia Hypothetical protein 0.0178 0.4628 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0257 0.0556
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0171 0.4418 0.5221
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0673 0.4383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0979 0.0875
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0163 0.4203 0.4961
Leishmania major hypothetical protein, conserved 0.0027 0.0273 0.0161
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0257 0.3211
Brugia malayi hypothetical protein 0.0036 0.0545 0.1179
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0561 0.099
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0066 0.139 0.1549
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0066 0.139 0.1291
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0545 0.0524
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0176 0.0138
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0673 0.124
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.2445 0.2828
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0066 0.139 0.1291
Entamoeba histolytica hypothetical protein 0.0036 0.0545 0.0956
Brugia malayi hypothetical protein 0.0027 0.0273 0.0589
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0979 0.0875
Echinococcus granulosus importin subunit beta 1 0.0029 0.0333 0.0266
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.1321 0.1221
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0673 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0828 0.0867
Schistosoma mansoni hypothetical protein 0.0308 0.8357 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0178 0.4628 0.5475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0828 0.0867
Trypanosoma brucei polo-like protein kinase 0.0102 0.2445 0.2358
Trichomonas vaginalis chaperonin, putative 0.0026 0.0257 0.0318
Plasmodium falciparum importin beta, putative 0.0029 0.0333 0.4899
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0545 0.0524
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0673 0.0566
Schistosoma mansoni hypothetical protein 0.0164 0.4215 0.4975
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0333 0.0266
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1321 0.1464
Entamoeba histolytica CAAX prenyl protease, putative 0.0066 0.139 0.2828
Giardia lamblia Kinase, PLK 0.0102 0.2445 0.5165
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Echinococcus multilocularis snurportin 1 0.0308 0.8357 1
Schistosoma mansoni hypothetical protein 0.0036 0.0545 0.0524
Toxoplasma gondii hypothetical protein 0.0037 0.0561 0.3501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0545 0.0524
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0257 0.0145
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0273 0.1244
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0066 0.139 0.1291
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0561 0.0022
Loa Loa (eye worm) hypothetical protein 0.0091 0.2124 0.2438
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.2124 0.2438
Echinococcus multilocularis caax prenyl protease 1 0.0066 0.139 0.1549
Loa Loa (eye worm) peptidase family M48 containing protein 0.0066 0.139 0.1549
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0257 0.0174
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.2445 0.2358
Entamoeba histolytica CAAX prenyl protease family 0.0178 0.4628 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0333 0.4899
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.139 0.2828
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.4471 0.4407
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0273 0.0161
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.2124 0.2438
Entamoeba histolytica hypothetical protein 0.0036 0.0545 0.0956
Echinococcus multilocularis CAAX prenyl protease 2 0.0178 0.4628 0.5475
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.2445 0.2828
Loa Loa (eye worm) hypothetical protein 0.0178 0.4628 0.5475
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.2445 0.2828
Echinococcus granulosus caax prenyl protease 1 0.0066 0.139 0.1549
Schistosoma mansoni inositol monophosphatase 0.0041 0.0673 0.0679
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.1321 0.1718
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0673 0.5
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0257 0.1124
Loa Loa (eye worm) hypothetical protein 0.0171 0.4418 0.5221
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.2445 0.2358
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0066 0.139 0.1291
Entamoeba histolytica hypothetical protein 0.0023 0.0176 0.0138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0828 0.0867
Toxoplasma gondii CAAX amino terminal protease family protein 0.0037 0.0561 0.3501
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0273 0.0161
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.139 0.2828
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1321 0.1699
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0561 0.0022
Mycobacterium tuberculosis Probable integral membrane protein 0.0037 0.0561 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0828 0.179
Echinococcus granulosus geminin 0.0164 0.4215 0.4975
Brugia malayi Trypsin family protein 0.0091 0.2124 0.4589
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0257 0.0174
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.8357 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.5032 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0673 0.0679
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0333 0.1715
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.5032 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0828 0.0867
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0673 0.0566
Treponema pallidum hypothetical protein 0.0037 0.0561 0.5
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0257 0.0174
Brugia malayi CAAX amino terminal protease family protein 0.0178 0.4628 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1198 0.1315
Echinococcus multilocularis geminin 0.0164 0.4215 0.4975
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Echinococcus granulosus snurportin 1 0.0308 0.8357 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0828 0.0867
Brugia malayi RNA, U transporter 1 0.0082 0.1862 0.4024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0176 0.0063
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0257 0.0174
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0171 0.4418 0.9547
Toxoplasma gondii hypothetical protein 0.0059 0.1196 0.848
Loa Loa (eye worm) hypothetical protein 0.0091 0.2124 0.2438
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0273 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4471 0.4407
Schistosoma mansoni hypothetical protein 0.0164 0.4215 0.4975
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0979 0.0875
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0273 0.3553
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.096 0.1874
Trypanosoma brucei CAAX amino terminal protease, putative 0.0178 0.4628 0.4566
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.1321 0.2854
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.2445 0.2358
Plasmodium vivax protease, putative 0.0037 0.0561 1
Echinococcus granulosus potassium voltage gated channel protein 0.0171 0.4418 0.5221
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0178 0.4628 0.5475
Entamoeba histolytica hypothetical protein 0.0036 0.0545 0.0956
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0257 0.0145
Echinococcus granulosus CAAX prenyl protease 2 0.0178 0.4628 0.5475
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4471 0.4407
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.2445 0.5165
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0273 0.3553
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0273 0.3553
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.096 0.1874
Leishmania major importin beta-1 subunit, putative 0.0023 0.0176 0.0063
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0257 0.0174
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0673 0.0679
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0561 0.099

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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