Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0106 | 0.0649 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0106 | 0.0649 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Echinococcus granulosus | zinc finger protein | 0.1128 | 0.9118 | 0.9057 |
Leishmania major | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Trypanosoma cruzi | GUP1, putative | 0.0106 | 0.0649 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.0649 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0106 | 0.0649 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0106 | 0.0649 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0106 | 0.0649 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Onchocerca volvulus | 0.0106 | 0.0649 | 0.5 | |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0106 | 0.0649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0649 | 0.0649 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0649 | 0.5 |
Brugia malayi | Hhat protein | 0.0106 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0649 | 0.0649 |
Toxoplasma gondii | hypothetical protein | 0.0106 | 0.0649 | 1 |
Loa Loa (eye worm) | hhat protein | 0.0106 | 0.0649 | 0.0649 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0649 | 0.5 |
Brugia malayi | diacylglycerol acyltransferase | 0.0106 | 0.0649 | 0.0649 |
Brugia malayi | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Brugia malayi | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0649 | 0.0649 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Brugia malayi | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Leishmania major | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0106 | 0.0649 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0106 | 0.0649 | 1 |
Loa Loa (eye worm) | hhat protein | 0.0106 | 0.0649 | 0.0649 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0106 | 0.0649 | 0.0649 |
Trichomonas vaginalis | porcupine, putative | 0.0106 | 0.0649 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.1235 | 1 | 1 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0106 | 0.0649 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.1235 | 1 | 1 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0106 | 0.0649 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.1128 | 0.9118 | 0.9057 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0649 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.1235 | 1 | 1 |
Trypanosoma cruzi | GUP1, putative | 0.0106 | 0.0649 | 1 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0649 | 0.0649 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0904 | 0.7256 | 0.7065 |
Loa Loa (eye worm) | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Brugia malayi | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0106 | 0.0649 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0106 | 0.0649 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0106 | 0.0649 | 0.0649 |
Leishmania major | glycerol uptake protein, putative | 0.0106 | 0.0649 | 1 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0106 | 0.0649 | 0.0649 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 300 uM | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 20833451 |
IC50 (functional) | > 300 uM | Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 20833451 |
IC50 (functional) | > 300 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 20833451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.