Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | 0.0175 | 0.5831 | 0.5831 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Echinococcus granulosus | ankyrin repeat protein | 0.0155 | 0.5086 | 0.5086 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.152 | 0.152 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.152 | 0.152 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.152 | 0.152 |
Onchocerca volvulus | 0.0058 | 0.1446 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0803 | 0.0803 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.1446 | 0.1502 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.152 | 0.152 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0155 | 0.5086 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0803 | 0.0803 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1446 | 0.1502 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0175 | 0.5822 | 0.5822 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0155 | 0.5086 | 0.5086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.