Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Onchocerca volvulus | 0.0043 | 0.0928 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0928 | 0.4041 |
Trichomonas vaginalis | hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0031 | 0.0431 | 0.1011 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.013 | 0.4268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0928 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0928 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0928 | 0.2176 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0082 | 0.2401 | 0.7285 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0928 | 0.4041 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0031 | 0.0431 | 0.1011 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0928 | 0.0928 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0928 | 0.0928 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0928 | 0.2176 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0928 | 0.0928 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0928 | 0.0928 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0928 | 0.2176 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0079 | 0.2298 | 0.6971 |
Trichomonas vaginalis | neuroendocrine convertase 2 precursor, putative | 0.0025 | 0.0217 | 0.0943 |
Brugia malayi | celfurPC protein | 0.0105 | 0.3296 | 0.7724 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0079 | 0.2298 | 1 |
Trichomonas vaginalis | leucine-rich repeat protein, BspA family | 0.0025 | 0.0217 | 0.0943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0928 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0079 | 0.2298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Echinococcus granulosus | Furin 1 | 0.0031 | 0.0431 | 0.1011 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Trichomonas vaginalis | proprotein convertase subtilisin/kexin type, putative | 0.0025 | 0.0217 | 0.0943 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0928 | 0.0928 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0928 | 0.0928 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0928 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.013 | 0.4268 | 1 |
Giardia lamblia | Furin precursor putative serine protease | 0.0025 | 0.0217 | 0.1949 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0928 | 0.2817 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0928 | 0.0928 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0928 | 0.2176 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Onchocerca volvulus | 0.0043 | 0.0928 | 0.5 | |
Loa Loa (eye worm) | endoprotease bli-4 | 0.013 | 0.4268 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0928 | 0.4041 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0056 | 0.143 | 0.335 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0079 | 0.2298 | 0.5384 |
Brugia malayi | proprotein convertase 2 | 0.0082 | 0.2401 | 0.5627 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0928 | 0.2176 |
Echinococcus multilocularis | Furin 1 | 0.0031 | 0.0431 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.4268 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0928 | 0.5 |
Echinococcus granulosus | furin | 0.013 | 0.4268 | 1 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0082 | 0.2401 | 0.5627 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0928 | 0.2176 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0928 | 0.2176 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0928 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0928 | 0.0928 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | 0.0105 | 0.3296 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0928 | 0.4041 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1215 | 0.2847 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0928 | 0.4041 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0217 | 0.0508 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0048 | 0.1111 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0082 | 0.2401 | 0.5627 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0928 | 0.4041 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0928 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0928 | 0.0928 |
Onchocerca volvulus | 0.0043 | 0.0928 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0217 | 0.0943 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0031 | 0.0431 | 0.1877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.