Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0526 | 0.2808 | 0.7261 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0147 | 0.0482 | 0.1718 |
Brugia malayi | Hyaluronidase family protein | 0.0526 | 0.2808 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0467 | 0.1664 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0214 | 0.0898 | 0.3198 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0214 | 0.0898 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0898 | 0.3198 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0699 | 0.3867 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0699 | 0.3867 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0526 | 0.2808 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0526 | 0.2808 | 0.7261 |
Schistosoma mansoni | Hyaluronidase | 0.0526 | 0.2808 | 0.7261 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0467 | 0.1664 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0699 | 0.3867 | 0.3867 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0954 | 0.3397 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0214 | 0.0898 | 0.3198 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.0482 | 0.1247 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0526 | 0.2808 | 0.2808 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0482 | 0.1718 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0467 | 0.1664 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.