Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.0068 | 0.0041 | 0.0417 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0121 | 1 |
Echinococcus multilocularis | geminin | 0.0198 | 0.0148 | 0.192 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0028 | 0.2355 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0014 | 0.1153 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0121 | 0.1485 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0028 | 0.1696 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0806 | 0.0651 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.0088 | 0.7086 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0121 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.0041 | 0.0417 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0028 | 0.0228 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0121 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0806 | 0.0651 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0048 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0028 | 0.0228 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0048 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.0041 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0014 | 0.0473 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0043 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0121 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0121 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0121 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0048 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0009 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0028 | 0.0228 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0043 | 0.0232 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.0041 | 0.0194 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0028 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0041 | 0.2841 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0043 | 0.0455 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0148 | 0.2104 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.0088 | 0.7294 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0009 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.0041 | 0.0194 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0028 | 0.2288 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.0041 | 0.0194 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.0121 | 0.0078 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.0041 | 0.0194 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.0121 | 0.1679 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.0041 | 0.2841 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0009 | 0.0714 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 1.2114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0028 | 0.1696 |
Echinococcus granulosus | geminin | 0.0198 | 0.0148 | 0.192 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.0041 | 0.0194 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0009 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.0048 | 0.5 |
Mycobacterium ulcerans | histidinol dehydrogenase | 1.2114 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.0041 | 0.0194 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0043 | 0.0232 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0043 | 0.0455 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0148 | 0.2104 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0028 | 0.2288 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.0041 | 0.3352 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0043 | 0.3056 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0806 | 0.0651 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0121 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.0088 | 0.7086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 nM | Inhibition of HMGR in rat hepatic microsomes assessed as conversion of [14C]HMG-CoA to [14C]mevalonic acid | ChEMBL. | 18412317 |
permeability (ADMET) | < 15 nm/s | Apparent permeability across human Caco-2 cells | ChEMBL. | 18412317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.