Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 2 associated protein 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_134982 | All targets in OG5_134982 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | WD repeat domain phosphoinositide-interacting protein, putative | cyclin-dependent kinase 2 associated protein 1 | 87 aa | 72 aa | 31.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0282 | 0.4247 | 1 |
Echinococcus multilocularis | smad | 0.0013 | 0.0052 | 0.0052 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.3003 | 0.707 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0064 | 0.0013 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0013 | 0.0052 | 0.0052 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0178 | 0.5 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.0188 | 0.2787 | 0.6561 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0178 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0013 | 0.0052 | 0.0122 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.3003 | 0.3141 |
Brugia malayi | hypothetical protein | 0.0616 | 0.9447 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0013 | 0.0052 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.4247 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0185 | 0.274 | 0.9108 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0013 | 0.0052 | 0.0122 |
Echinococcus multilocularis | Smad4 | 0.0013 | 0.0052 | 0.0052 |
Schistosoma mansoni | Smad4 | 0.0013 | 0.0052 | 0.0122 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.0188 | 0.2787 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.3003 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0021 | 0.0178 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0013 | 0.0052 | 0.0052 |
Schistosoma mansoni | smad | 0.0013 | 0.0052 | 0.0122 |
Echinococcus granulosus | Smad4 | 0.0013 | 0.0052 | 0.0122 |
Schistosoma mansoni | smad1 5 8 and | 0.0013 | 0.0052 | 0.0122 |
Schistosoma mansoni | smad1 5 8 and | 0.0013 | 0.0052 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0178 | 0.0134 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0178 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0178 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0185 | 0.274 | 0.9108 |
Brugia malayi | MH2 domain containing protein | 0.0185 | 0.274 | 0.2861 |
Echinococcus multilocularis | geminin | 0.0282 | 0.4247 | 0.4247 |
Echinococcus granulosus | smad | 0.0013 | 0.0052 | 0.0122 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0178 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0021 | 0.0178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0178 | 0.0428 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.0188 | 0.2787 | 0.2787 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.0188 | 0.2787 | 0.6561 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0013 | 0.0052 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.2787 | 0.9268 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0021 | 0.0178 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.4247 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.02 uM | Abrogation of camptothecin induced cell cycle arrest at G2/M phase in human HT29 cells | ChEMBL. | 18547806 |
IC50 (binding) | = 0.011 uM | Inhibition of Chk1 | ChEMBL. | 18547806 |
IC50 (binding) | = 5.6 uM | Inhibition of Cdk1 | ChEMBL. | 18547806 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18547806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.