Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.003 | 1 | 1 | |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.081 | 0.081 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.2124 | 0.2124 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | lamin | 0.003 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.2933 | 0.2309 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.081 | 0.081 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.081 | 0.081 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | lamin | 0.003 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.2124 | 0.143 |
Schistosoma mansoni | lamin | 0.003 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.081 | 0.081 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.081 | 0.081 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1846 | 0.1127 |
Onchocerca volvulus | 0.003 | 1 | 1 | |
Echinococcus granulosus | lamin | 0.003 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.081 | 0.081 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.9722 | 0.9697 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.081 | 0.081 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.2933 | 0.2309 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.081 | 0.081 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1846 | 0.1127 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.081 | 0.081 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.081 | 0.081 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.2124 | 0.2124 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.081 | 0.081 |
Echinococcus multilocularis | musashi | 0.003 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.081 | 0.081 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.081 | 0.081 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.081 | 0.081 |
Echinococcus granulosus | lamin dm0 | 0.003 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.