Detailed information for compound 1256130

Basic information

Technical information
  • TDR Targets ID: 1256130
  • Name: ethyl 4-(furan-2-ylmethylcarbamoyl)-3,5-dimet hyl-1H-pyrrole-2-carboxylate
  • MW: 290.314 | Formula: C15H18N2O4
  • H donors: 2 H acceptors: 2 LogP: 1.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1[nH]c(c(c1C)C(=O)NCc1ccco1)C
  • InChi: 1S/C15H18N2O4/c1-4-20-15(19)13-9(2)12(10(3)17-13)14(18)16-8-11-6-5-7-21-11/h5-7,17H,4,8H2,1-3H3,(H,16,18)
  • InChiKey: YHOGZPKCCYBWDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 4-(2-furylmethylcarbamoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
  • 4-[(2-furylmethylamino)-oxomethyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester
  • 4-(2-furylmethylcarbamoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester
  • MLS000686687
  • SMR000339765
  • ethyl 4-{[(2-furylmethyl)amino]carbonyl}-3,5-dimethyl-1H-pyrrole-2-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.2269 0.2269
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.2269 0.2269
Echinococcus granulosus ryanodine receptor 44f 0.0025 0.2269 0.2269
Echinococcus granulosus intermediate filament protein 0.0033 0.4263 0.4263
Loa Loa (eye worm) voltage-gated potassium channel 0.0025 0.2269 0.2269
Echinococcus multilocularis sodium channel protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) voltage-gated calcium channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0025 0.2269 0.1915
Echinococcus multilocularis potassium voltage gated channel protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Brugia malayi Cyclic-nucleotide gated cation channel 0.0025 0.2269 0.1915
Loa Loa (eye worm) hypothetical protein 0.0032 0.4113 0.4113
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 1 1
Echinococcus multilocularis lamin dm0 0.0033 0.4263 0.4263
Echinococcus granulosus short transient receptor potential channel 6 0.0025 0.2269 0.2269
Onchocerca volvulus 0.0033 0.4263 1
Brugia malayi intermediate filament protein 0.0033 0.4263 0.4001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.2269 0.5
Schistosoma mansoni intermediate filament proteins 0.0033 0.4263 0.258
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.2269 0.5
Echinococcus multilocularis two pore calcium channel protein 2 0.0025 0.2269 0.2269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 1 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0025 0.2269 0.2269
Echinococcus multilocularis sodium leak channel non selective protein 0.0025 0.2269 0.2269
Echinococcus multilocularis transient receptor potential gamma protein 0.0025 0.2269 0.2269
Brugia malayi cation channel family protein 0.0025 0.2269 0.1915
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0438 0.0438
Echinococcus multilocularis short transient receptor potential channel 6 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0025 0.2269 0.1915
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0025 0.2269 0.2269
Loa Loa (eye worm) intermediate filament protein 0.0033 0.4263 0.4263
Echinococcus multilocularis potassium voltage gated channel protein 0.0025 0.2269 0.2269
Onchocerca volvulus 0.0033 0.4263 1
Leishmania major hypothetical protein, unknown function 0.0025 0.2269 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0025 0.2269 0.2269
Echinococcus granulosus TRP transient receptor potential channel 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Leishmania major hypothetical protein, conserved 0.0025 0.2269 0.5
Loa Loa (eye worm) ryanodine receptor 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0025 0.2269 0.1915
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0025 0.2269 0.2269
Echinococcus granulosus voltage gated potassium channel 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0025 0.2269 0.1915
Schistosoma mansoni lamin 0.0033 0.4263 0.258
Echinococcus granulosus shaker cognate 0.0025 0.2269 0.2269
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0025 0.2269 0.2269
Brugia malayi voltage-dependent calcium channel 0.0025 0.2269 0.1915
Echinococcus granulosus potassium voltage gated channel protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis shaker cognate 0.0025 0.2269 0.2269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0025 0.2269 0.2269
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0025 0.2269 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.2269 0.2269
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0025 0.2269 0.2269
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.4263 0.4001
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0025 0.2269 0.1915
Echinococcus granulosus short transient receptor potential channel 6 0.0025 0.2269 0.2269
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0025 0.2269 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Echinococcus granulosus potassium voltage gated channel protein 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0025 0.2269 0.2269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0025 0.2269 0.2269
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium large conductance calcium activated 0.0025 0.2269 0.2269
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0025 0.2269 0.2269
Echinococcus multilocularis musashi 0.0033 0.4263 0.4263
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.2269 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0025 0.2269 0.2269
Echinococcus multilocularis lamin 0.0033 0.4263 0.4263
Echinococcus granulosus sodium leak channel non selective protein 0.0025 0.2269 0.2269
Echinococcus granulosus voltage dependent calcium channel 0.0025 0.2269 0.2269
Echinococcus granulosus lamin dm0 0.0033 0.4263 0.4263
Echinococcus granulosus calcium activated potassium channel 0.0025 0.2269 0.2269
Echinococcus granulosus voltage gated potassium channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus potassium voltage gated channel protein 0.0025 0.2269 0.2269
Toxoplasma gondii hypothetical protein 0.0025 0.2269 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.2269 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0025 0.2269 0.2269
Echinococcus multilocularis short transient receptor potential channel 6 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0025 0.2269 0.1915
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Loa Loa (eye worm) calcium channel 0.0025 0.2269 0.2269
Echinococcus granulosus potassium large conductance calcium activated 0.0025 0.2269 0.2269
Echinococcus multilocularis ryanodine receptor 44f 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0025 0.2269 0.2269
Echinococcus granulosus potassium voltage gated channel protein 0.0025 0.2269 0.2269
Brugia malayi hypothetical protein 0.0025 0.2269 0.1915
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0025 0.2269 0.5
Schistosoma mansoni lamin 0.0033 0.4263 0.258
Echinococcus granulosus potassium voltage gated channel protein 0.0025 0.2269 0.2269
Echinococcus multilocularis transfer RNA-Gly 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Toxoplasma gondii transporter, cation channel family protein 0.0025 0.2269 0.5
Loa Loa (eye worm) voltage-dependent calcium channel 0.0025 0.2269 0.2269
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0033 0.4263 0.4263
Echinococcus granulosus voltage dependent calcium channel 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0025 0.2269 0.1915
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0025 0.2269 0.1915
Toxoplasma gondii transporter, cation channel family protein 0.0025 0.2269 0.5
Loa Loa (eye worm) ion channel NompC 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0025 0.2269 0.1915
Echinococcus granulosus two pore calcium channel protein 1 0.0025 0.2269 0.2269
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0025 0.2269 0.1915
Echinococcus multilocularis potassium voltage gated channel protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.4263 0.4263
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0025 0.2269 0.2269
Echinococcus multilocularis calcium activated potassium channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0025 0.2269 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel protein 0.0025 0.2269 0.2269
Toxoplasma gondii transporter, cation channel family protein 0.0025 0.2269 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Brugia malayi ion channel NompC 0.0025 0.2269 0.1915
Echinococcus granulosus sodium channel protein 0.0025 0.2269 0.2269
Echinococcus multilocularis two pore calcium channel protein 1 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0025 0.2269 0.5
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0025 0.2269 0.2269
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage gated potassium channel 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0025 0.2269 0.1915
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.2269 0.2269
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0025 0.2269 0.1915
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Brugia malayi cation channel family protein 0.0025 0.2269 0.1915
Echinococcus multilocularis voltage dependent calcium channel 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) voltage-gated potassium channel 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage dependent calcium channel 0.0025 0.2269 0.2269
Echinococcus granulosus lamin 0.0033 0.4263 0.4263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 1 1
Toxoplasma gondii hypothetical protein 0.0025 0.2269 0.5
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0025 0.2269 0.1915
Echinococcus granulosus two pore calcium channel protein 2 0.0025 0.2269 0.2269
Echinococcus granulosus voltage gated hydrogen channel 1 0.0025 0.2269 0.2269
Loa Loa (eye worm) hypothetical protein 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0025 0.2269 0.1915
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0025 0.2269 0.2269
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0025 0.2269 0.1915
Brugia malayi olfactory channel protein osm-9 0.0025 0.2269 0.1915
Echinococcus multilocularis transient receptor potential cation channel 0.0025 0.2269 0.2269
Brugia malayi Transient-receptor-potential like protein 0.0025 0.2269 0.1915
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential gamma protein 0.0025 0.2269 0.2269
Brugia malayi Cytochrome P450 family protein 0.0023 0.177 0.1393
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Echinococcus granulosus transient receptor potential cation channel 0.0025 0.2269 0.2269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0025 0.2269 0.2269
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0025 0.2269 0.2269
Echinococcus multilocularis conserved hypothetical protein 0.0025 0.2269 0.2269
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.177 0.177

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.005 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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