Detailed information for compound 1257650

Basic information

Technical information
  • TDR Targets ID: 1257650
  • Name: N-cyclohexyl-1-phenyltetrazol-5-amine
  • MW: 243.308 | Formula: C13H17N5
  • H donors: 1 H acceptors: 3 LogP: 3.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)Nc1nnnn1c1ccccc1
  • InChi: 1S/C13H17N5/c1-3-7-11(8-4-1)14-13-15-16-17-18(13)12-9-5-2-6-10-12/h2,5-6,9-11H,1,3-4,7-8H2,(H,14,15,17)
  • InChiKey: FGGHQJHLQVTLIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-1-phenyl-tetrazol-5-amine
  • N-cyclohexyl-1-phenyl-5-tetrazolamine
  • cyclohexyl-(1-phenyltetrazol-5-yl)amine
  • N-cyclohexyl-1-phenyl-1,2,3,4-tetrazol-5-amine
  • ZINC04516997
  • Oprea1_402363
  • 1-Phenyl-5-(cyclohexylamino)(1H)tetrazole
  • 1-Phenyl-5-(cyclohexylamino)-1H-tetrazole
  • AI-204/31687025
  • MLS000557800
  • SMR000178702
  • TimTec1_008467
  • BAS 09858661
  • Cyclohexyl-(1-phenyl-1H-tetrazol-5-yl)-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei histone deacetylase 3 0.0282 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.3582 0.3582
Loa Loa (eye worm) hypothetical protein 0.0146 0.3947 0.3947
Loa Loa (eye worm) hypothetical protein 0.0148 0.401 0.401
Plasmodium vivax histone deacetylase 2, putative 0.0282 0.8849 0.2124
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0278 0.8698 1
Echinococcus multilocularis histone deacetylase 1 0.0278 0.8698 0.9597
Toxoplasma gondii histone deacetylase HDAC1 0.0282 0.8849 0.8849
Schistosoma mansoni alpha-glucosidase 0.0142 0.38 0.4193
Trypanosoma brucei Polypeptide deformylase 1 0.0104 0.2442 0.2759
Toxoplasma gondii histone deacetylase HDAC2 0.0278 0.8698 0.8698
Loa Loa (eye worm) hypothetical protein 0.0142 0.3796 0.3796
Trypanosoma brucei histone deacetylase, putative 0.0282 0.8849 1
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.8849 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0146 0.3947 0.4355
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0104 0.2442 0.2759
Plasmodium falciparum histone deacetylase 1 0.0278 0.8698 0.5143
Schistosoma mansoni histone deacetylase 4 5 0.0282 0.8849 0.9763
Trypanosoma brucei histone deacetylase 4 0.0282 0.8849 1
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Echinococcus multilocularis histone deacetylase 6 0.0282 0.8849 0.9763
Loa Loa (eye worm) hypothetical protein 0.0278 0.8698 0.8698
Leishmania major polypeptide deformylase-like protein, putative 0.0104 0.2442 0.2759
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.4628 0.4628
Schistosoma mansoni histone deacetylase 0.0278 0.8698 0.9597
Plasmodium falciparum histone deacetylase, putative 0.0282 0.8849 1
Schistosoma mansoni histone deacetylase 0.0278 0.8698 0.9597
Loa Loa (eye worm) histone deacetylase 0.0282 0.8849 0.8849
Trypanosoma cruzi histone deacetylase 1, putative 0.0278 0.8698 0.983
Echinococcus granulosus histone deacetylase 3 0.0278 0.8698 0.9597
Brugia malayi Histone deacetylase 1 0.0278 0.8698 0.8698
Loa Loa (eye worm) histone deacetylase 3 0.0278 0.8698 0.8698
Onchocerca volvulus Huntingtin homolog 0.0148 0.401 1
Giardia lamblia Histone deacetylase 0.0278 0.8698 0.5
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0274 0.8538 0.5
Toxoplasma gondii hypothetical protein 0.0274 0.8538 0.8538
Toxoplasma gondii histone deacetylase HDAC4 0.0314 1 1
Echinococcus granulosus histone deacetylase 6 0.0282 0.8849 0.9763
Treponema pallidum polypeptide deformylase (def) 0.0274 0.8538 0.5
Schistosoma mansoni alpha-glucosidase 0.0142 0.38 0.4193
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.3947 0.4461
Trypanosoma brucei Peptide deformylase 2 0.0104 0.2442 0.2759
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.8849 1
Leishmania major histone deacetylase, putative 0.0282 0.8849 1
Trypanosoma brucei histone deacetylase 2 0.0146 0.3947 0.4461
Echinococcus granulosus histone deacetylase 8 0.0146 0.3947 0.4355
Echinococcus multilocularis histone deacetylase 6 0.0282 0.8849 0.9763
Plasmodium falciparum histone deacetylase 2 0.0282 0.8849 1
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.401 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.401 0.401
Leishmania major histone deacetylase, putative 0.0278 0.8698 0.983
Loa Loa (eye worm) histone deacetylase 1 0.0278 0.8698 0.8698
Trypanosoma cruzi Peptide deformylase 2, putative 0.0104 0.2442 0.2759
Loa Loa (eye worm) histone deacetylase 7A 0.0282 0.8849 0.8849
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.8849 1
Toxoplasma gondii histone deacetylase HDAC3 0.0278 0.8698 0.8698
Loa Loa (eye worm) hypothetical protein 0.0168 0.4733 0.4733
Echinococcus granulosus histone deacetylase 1 0.0278 0.8698 0.9597
Entamoeba histolytica histone deacetylase, putative 0.0278 0.8698 1
Trypanosoma brucei histone deacetylase 1 0.0278 0.8698 0.983
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.4628 0.5107
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0274 0.8538 0.5
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0274 0.8538 0.5
Plasmodium vivax histone deacetylase, putative 0.0314 1 1
Brugia malayi histone deacetylase 3 (HD3) 0.0278 0.8698 0.8698
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.3947 0.4461
Toxoplasma gondii histone deacetylase HDAC5 0.0146 0.3947 0.3947
Brugia malayi hypothetical protein 0.0148 0.401 0.401
Loa Loa (eye worm) histone deacetylase 11 0.0314 1 1
Brugia malayi Histone deacetylase family protein 0.0282 0.8849 0.8849
Brugia malayi histone deacetylase 1 (HD1) 0.0278 0.8698 0.8698
Schistosoma mansoni histone deacetylase 4 5 0.0282 0.8849 0.9763
Echinococcus granulosus histone deacetylase 6 0.0288 0.9063 1
Plasmodium vivax histone deacetylase 1, putative 0.0278 0.8698 0.1092
Schistosoma mansoni histone deacetylase hda2 0.0146 0.3947 0.4355
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Chlamydia trachomatis peptide deformylase 0.0274 0.8538 0.5
Echinococcus granulosus histone deacetylase 0.0282 0.8849 0.9763
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Leishmania major histone deacetylase, putative 0.0278 0.8698 0.983
Trichomonas vaginalis histone deacetylase, putative 0.0278 0.8698 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0104 0.2442 0.2759
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0278 0.8698 1
Mycobacterium ulcerans peptide deformylase 0.0274 0.8538 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.4628 0.4628
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0278 0.8698 1
Echinococcus granulosus histone deacetylase 6 0.0282 0.8849 0.9763
Echinococcus granulosus histone deacetylase 7 0.0282 0.8849 0.9763
Trypanosoma cruzi Peptide deformylase 2, putative 0.0104 0.2442 0.2759
Echinococcus multilocularis histone deacetylase 0.0282 0.8849 0.9763
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.4628 0.5107
Trypanosoma cruzi histone deacetylase 1, putative 0.0278 0.8698 0.983
Leishmania major histone deacetylase, putative 0.0282 0.8849 1
Plasmodium vivax histone deacetylase, putative 0.0282 0.8849 0.2124
Echinococcus multilocularis histone deacetylase 8 0.0146 0.3947 0.4355
Onchocerca volvulus Histone deacetylase 10 homolog 0.0146 0.3947 0.9667
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.4628 0.5107
Echinococcus multilocularis histone deacetylase 3 0.0278 0.8698 0.9597
Echinococcus multilocularis histone deacetylase 7 0.0282 0.8849 0.9763
Echinococcus multilocularis histone deacetylase 6 0.0288 0.9063 1
Brugia malayi Histone deacetylase family protein 0.0282 0.8849 0.8849
Schistosoma mansoni histone deacetylase hda2 0.0288 0.9063 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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