Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase A | Starlite/ChEMBL | References |
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0136 | 1 | 0.5 |
Brugia malayi | Peripheral plasma membrane protein CASK | 0.0031 | 0.0655 | 0.0655 |
Brugia malayi | serine/threonine kinase 12 | 0.0136 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0136 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.0754 | 0.5 | |
Loa Loa (eye worm) | guanylate kinase | 0.006 | 0.3204 | 0.3204 |
Leishmania major | protein kinase, putative | 0.0136 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | peripheral plasma membrane protein CASK | 0.0025 | 0.0099 | 0.0099 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0136 | 1 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0136 | 1 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0136 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0027 | 0.0295 | 0.0295 |
Schistosoma mansoni | cell polarity protein | 0.0072 | 0.4302 | 0.4302 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0136 | 1 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0136 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0136 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0136 | 1 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | peripheral plasma membrane protein CASK | 0.0025 | 0.0099 | 0.0099 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0136 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 1 | 1 |
Giardia lamblia | Aurora kinase | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 1 | 1 |
Echinococcus granulosus | disks large 3 | 0.0072 | 0.4302 | 0.4302 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0136 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | lethal(1)discs large-1 tumor suppressor | 0.0068 | 0.3943 | 0.3943 |
Echinococcus multilocularis | disks large 3 | 0.0072 | 0.4302 | 0.4302 |
Trichomonas vaginalis | AGC family protein kinase | 0.0136 | 1 | 0.5 |
Brugia malayi | Guanylate kinase family protein | 0.008 | 0.4957 | 0.4957 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0136 | 1 | 1 |
Schistosoma mansoni | MAGUK homolog | 0.0025 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0136 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.