TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.824 | Formula: C18H20ClN3O
H donors: 1 H acceptors: 1 LogP: 3.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C1CN[C@@H](C1)COc1cncc(c1)n1ccc2c1cccc2.Cl
InChi: 1S/C18H19N3O.ClH/c1-2-6-18-14(4-1)7-9-21(18)16-10-17(12-19-11-16)22-13-15-5-3-8-20-15;/h1-2,4,6-7,9-12,15,20H,3,5,8,13H2;1H/t15-;/m0./s1
InChiKey: JQCSLHYVXFUULS-RSAXXLAASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neuronal acetylcholine receptor; alpha2/beta4	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, nicotinic, alpha 4 (neuronal)	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha4/beta4	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha3/beta2	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha3/beta4	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha4/beta2	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha2/beta2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Onchocerca volvulus	Putative nachr subunit	Get druggable targets OG5_128160	All targets in OG5_128160

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	507 aa	37.9 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	492 aa	39.8 %
Onchocerca volvulus	Putative zinc finger protein	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	509 aa	40.3 %
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	532 aa	24.2 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	482 aa	42.5 %
Brugia malayi	Cation transporter family protein	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	482 aa	32.8 %
Schistosoma mansoni	nAChR subunit	Neuronal acetylcholine receptor; alpha3/beta4	499 aa	538 aa	24.9 %
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	Neuronal acetylcholine receptor; alpha3/beta4	499 aa	569 aa	25.5 %
Onchocerca volvulus		Neuronal acetylcholine receptor; alpha3/beta2	500 aa	477 aa	39.2 %
Onchocerca volvulus	39S ribosomal protein L13, mitochondrial homolog	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	463 aa	36.1 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	516 aa	42.1 %
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	481 aa	38.0 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	482 aa	42.5 %
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	510 aa	38.6 %
Onchocerca volvulus		Neuronal acetylcholine receptor; alpha2/beta4	495 aa	502 aa	40.0 %
Schistosoma mansoni	nAChR subunit	Neuronal acetylcholine receptor; alpha3/beta4	499 aa	546 aa	26.0 %
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	508 aa	34.3 %
Echinococcus multilocularis	nAChR subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	476 aa	30.3 %
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	502 aa	34.7 %
Onchocerca volvulus		Neuronal acetylcholine receptor; alpha3/beta2	500 aa	500 aa	33.8 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-3 precursor, putative	Neuronal acetylcholine receptor; alpha2/beta4	495 aa	501 aa	23.4 %
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	524 aa	38.7 %
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	491 aa	37.7 %
Onchocerca volvulus		Neuronal acetylcholine receptor; alpha3/beta2	500 aa	463 aa	36.1 %
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	486 aa	24.3 %
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	487 aa	34.3 %
Drosophila melanogaster	nicotinic Acetylcholine Receptor alpha2	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	511 aa	40.9 %
Loa Loa (eye worm)	hypothetical protein	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	521 aa	40.1 %
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	Neuronal acetylcholine receptor; alpha3/beta4	499 aa	569 aa	25.8 %
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	Neuronal acetylcholine receptor; alpha3/beta2	500 aa	476 aa	41.4 %
Onchocerca volvulus		Neuronal acetylcholine receptor; alpha3/beta4	499 aa	549 aa	24.0 %
Echinococcus granulosus	acetylcholine receptor subunit beta 1	Neuronal acetylcholine receptor; alpha3/beta4	499 aa	523 aa	35.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0143	0.4741	0.7822
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.3589	0.3589
Schistosoma mansoni	neurotransmitter gated ion channel	0.0077	0.0682	0.1124
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0143	0.4741	0.7822
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0077	0.0682	0.1124
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Echinococcus granulosus	glycine receptor subunit beta	0.0143	0.4741	0.4741
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0143	0.4741	0.7822
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Echinococcus multilocularis	nAChR subunit	0.0077	0.0682	0.0682
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0143	0.4741	0.7822
Onchocerca volvulus		0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0228	1	1
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Onchocerca volvulus		0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Echinococcus multilocularis	glycine receptor subunit beta	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0143	0.4741	0.4741
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0143	0.4741	0.4741
Entamoeba histolytica	hypothetical protein	0.0077	0.0682	0.5
Onchocerca volvulus		0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Brugia malayi	RNA binding protein	0.0124	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.3589	0.3589
Echinococcus granulosus	nAChR subunit	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0077	0.0682	0.0682
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0143	0.4741	0.4741
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0143	0.4741	0.4741
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0143	0.4741	0.7822
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0228	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0143	0.4741	0.4741
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3589	0.5922
Onchocerca volvulus		0.0077	0.0682	0.0682
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Echinococcus granulosus	tar DNA binding protein	0.0124	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0228	1	1
Echinococcus multilocularis	geminin	0.0164	0.6061	0.6061
Echinococcus multilocularis	nAChR subunit	0.0143	0.4741	0.4741
Loa Loa (eye worm)	GABA receptor subunit	0.0077	0.0682	0.0682
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3589	0.5922
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0143	0.4741	0.4741
Echinococcus granulosus	nAChR subunit	0.0077	0.0682	0.0682
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0143	0.4741	0.4741
Brugia malayi	Cation transporter family protein	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0228	1	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0077	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0228	1	1
Brugia malayi	TAR-binding protein	0.0124	0.3589	0.3589
Echinococcus multilocularis	glycine receptor subunit beta	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0143	0.4741	0.7822
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Schistosoma mansoni	hypothetical protein	0.0164	0.6061	1
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3589	0.5922
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0143	0.4741	0.4741
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0143	0.4741	0.4741
Onchocerca volvulus		0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Echinococcus granulosus	glycine receptor subunit beta	0.0143	0.4741	0.4741
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0143	0.4741	0.4741
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0228	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0077	0.0682	0.1124
Schistosoma mansoni	hypothetical protein	0.0164	0.6061	1
Loa Loa (eye worm)	ACC-1 protein	0.0143	0.4741	0.4741
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0077	0.0682	0.0682
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0143	0.4741	0.4741
Onchocerca volvulus	Putative nachr subunit	0.0228	1	1
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Schistosoma mansoni	nAChR subunit	0.0143	0.4741	0.7822
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0143	0.4741	0.4741
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0143	0.4741	0.4741
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0143	0.4741	0.4741
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3589	0.5922
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0143	0.4741	0.4741
Loa Loa (eye worm)	RNA binding protein	0.0124	0.3589	0.3589
Echinococcus granulosus	geminin	0.0164	0.6061	0.6061
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0143	0.4741	0.4741
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3589	0.5922
Loa Loa (eye worm)	LGC-31 protein	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0077	0.0682	0.0682
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0143	0.4741	0.4741
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0143	0.4741	0.4741
Brugia malayi	Cation transporter family protein	0.0143	0.4741	0.4741
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0143	0.4741	0.4741
Onchocerca volvulus		0.0143	0.4741	0.4741
Brugia malayi	excitatory GABA receptor EXP-1A	0.0143	0.4741	0.4741
Onchocerca volvulus		0.0077	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0682	0.0682
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0143	0.4741	0.4741
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0143	0.4741	0.4741
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0228	1	1
Loa Loa (eye worm)	ACC-1 protein	0.0143	0.4741	0.4741
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0143	0.4741	0.4741
Brugia malayi	Cation transporter family protein	0.0143	0.4741	0.4741
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0228	1	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Onchocerca volvulus		0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4741	0.4741
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.3589	0.3589

Activities

Activity type	Activity value	Assay description	Source	Reference
Efficacy (functional)	= 0 %	Agonist activity at human nAChR alpha4beta2 in human SH-EP1 cells assessed as induction in rubidium efflux relative to carbamylcholine	ChEMBL.	20822184
Efficacy (binding)	= 85 %	Inactivation of nAChR alpha4beta2 in human SH-EP1 cells relative to carbamylcholine	ChEMBL.	20822184
IC50 (binding)	= 0.78 uM	Inactivation of nAChR alpha4beta2 in human SH-EP1 cells	ChEMBL.	20822184
Ki (binding)	= 2.4 nM	Displacement of [3H]epibatidine from rat nAChR alpha4beta2	ChEMBL.	20822184
Ki (binding)	= 6.5 nM	Displacement of [3H]epibatidine from rat nAChR alpha2beta2	ChEMBL.	20822184
Ki (binding)	= 55.3 nM	Displacement of [3H]epibatidine from rat forebrain nAChR alpha4beta2	ChEMBL.	20822184
Ki (binding)	= 70.6 nM	Displacement of [3H]epibatidine from rat nAChR alpha4beta4	ChEMBL.	20822184
Ki (binding)	= 104 nM	Displacement of [3H]epibatidine from rat nAChR alpha2beta4	ChEMBL.	20822184
Ki (binding)	= 208 nM	Displacement of [3H]epibatidine from rat nAChR alpha3beta2	ChEMBL.	20822184
Ki (binding)	= 793 nM	Displacement of [3H]epibatidine from rat nAChR alpha3beta4	ChEMBL.	20822184

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1258685

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1259103