TDR Targets

Basic information

Technical information

TDR Targets ID: 1262121
Name: 7,8-dihydroxy-3-(4-methoxyphenyl)chromen-4-on e
MW: 284.263 | Formula: C16H12O5
H donors: 2 H acceptors: 3 LogP: 2.44 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1coc2c(c1=O)ccc(c2O)O
InChi: 1S/C16H12O5/c1-20-10-4-2-9(3-5-10)12-8-21-16-11(14(12)18)6-7-13(17)15(16)19/h2-8,17,19H,1H3
InChiKey: DLXIJJURUIXRFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7,8-dihydroxy-3-(4-methoxyphenyl)-4-chromenone
7,8-dihydroxy-3-(4-methoxyphenyl)chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	fkbp-rapamycin associated protein	0.001	0.0063	0.0063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Entamoeba histolytica	hypothetical protein	0.0024	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.001	0.0063	0.0063
Echinococcus granulosus	serine protein kinase ATM	0.0024	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0854	0.0796
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma cruzi	target of rapamycin kinase 3	0.0017	0.5415	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0854	0.1118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Onchocerca volvulus		0.001	0	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.5415	0.7089
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0017	0.5415	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0017	0.5415	0.5386
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.001	0.0063	0.0063
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.5415	0.7089
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.5415	0.5415
Giardia lamblia	GTOR	0.0017	0.5415	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0854	0.0796
Loa Loa (eye worm)	hypothetical protein	0.002	0.7638	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.002	0.7638	0.7623
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0017	0.5415	0.4987
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0017	0.5415	0.5415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0017	0.5415	0.5386
Echinococcus multilocularis	serine protein kinase ATM	0.0024	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0017	0.5439	0.541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0017	0.5415	0.5415
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.5415	0.5415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0017	0.5415	0.5415
Onchocerca volvulus	Bile acid receptor homolog	0.001	0	0.5
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0024	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0017	0.5415	0.5415
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0017	0.5415	0.5415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0017	0.5415	0.4987
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0017	0.5415	0.4987
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0017	0.5415	0.4987
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0017	0.5439	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.001	0.0063	0.0063
Toxoplasma gondii	FATC domain-containing protein	0.0024	1	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0017	0.5415	0.5415
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0017	0.5415	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0017	0.5415	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.5415	0.5386
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0024	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1290231

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1262121