Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.6603 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0041 | 0.0605 | 1 |
Echinococcus multilocularis | 0.0041 | 0.0605 | 0.0368 | |
Schistosoma mansoni | amine oxidase | 0.0041 | 0.0605 | 0.0605 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0605 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0041 | 0.0605 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0246 | 0.0246 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0041 | 0.0605 | 1 |
Schistosoma mansoni | amine oxidase | 0.0041 | 0.0605 | 0.0605 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0041 | 0.0605 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.1249 | 0.1029 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.1091 | 0.1091 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.0588 | 0.0351 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0246 | 0.0246 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0703 | 0.1065 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0041 | 0.0605 | 0.0476 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.7628 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0861 | 0.1304 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0041 | 0.0605 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0246 | 0.0372 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.1249 | 0.1246 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.0861 | 0.0968 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.6603 | 1 |
Onchocerca volvulus | 0.0246 | 0.7628 | 1 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0246 | 0.0047 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0315 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0315 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0274 | 0.8576 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0315 | 1 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0041 | 0.0605 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0041 | 0.0605 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0041 | 0.0605 | 0.0476 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0605 | 0.0565 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0041 | 0.0605 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.0588 | 0.0456 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0041 | 0.0605 | 0.0368 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0315 | 1 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0041 | 0.0605 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0041 | 0.0605 | 0.0916 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0041 | 0.0605 | 0.0605 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1249 | 0.1578 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0588 | 0.0588 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0041 | 0.0605 | 0.0916 |
Onchocerca volvulus | 0.0041 | 0.0605 | 0.0486 | |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0274 | 0.8576 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0041 | 0.0605 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0605 | 0.0916 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 6 | Positive modulation of GluR1 | ChEMBL. | 20817521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.