Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.6156 | 0.5789 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0871 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5742 | 0.5335 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.6156 | 0.7251 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0871 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.849 | 0.8346 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0871 | 0.1601 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.4963 | 0.5846 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0871 | 0.0898 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0147 | 0.849 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.4963 | 0.9124 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0871 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4963 | 0.4483 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.9699 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0871 | 0.1026 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.6156 | 0.5789 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0871 | 0.1601 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0871 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0871 | 0.0898 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0871 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.8875 | 0.8768 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0147 | 0.849 | 0.8346 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0147 | 0.849 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.544 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0871 | 0.1026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 93 nM | Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]G | ChEMBL. | 21074428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.