Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.2126 | 0.2007 |
Brugia malayi | Matrixin family protein | 0.0258 | 0.2126 | 0.2007 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.2812 | 0.3364 |
Brugia malayi | Hemopexin family protein | 0.0332 | 0.302 | 0.3775 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0315 | 0.2812 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0258 | 0.2126 | 0.6563 |
Loa Loa (eye worm) | matrixin family protein | 0.059 | 0.6167 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.1111 | 0.2662 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0905 | 1 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0147 | 0.0769 | 0.0769 |
Brugia malayi | Matrixin family protein | 0.0258 | 0.2126 | 0.2007 |
Mycobacterium ulcerans | hydrolase | 0.0315 | 0.2812 | 0.5 |
Brugia malayi | Matrixin family protein | 0.059 | 0.6167 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0573 | 0.5959 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0315 | 0.2812 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0573 | 0.5959 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0134 | 0.0606 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.2126 | 0.2007 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 0.302 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | matrixin family protein | 0.0573 | 0.5959 | 0.9589 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.2399 | 0.2548 |
Brugia malayi | Matrixin family protein | 0.0258 | 0.2126 | 0.2007 |
Brugia malayi | Matrixin family protein | 0.0258 | 0.2126 | 0.2007 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0134 | 0.0606 | 0.0721 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0315 | 0.2812 | 0.3364 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.2126 | 0.2007 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0258 | 0.2126 | 0.2007 |
Onchocerca volvulus | 0.0332 | 0.302 | 0.2332 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.1051 | 0.1051 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.