Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0442 | 0.3723 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0307 | 0.0358 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0055 | 0.0401 | 0.0467 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0035 | 0.0035 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1172 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0442 | 0.3723 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0368 | 0.0429 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0035 | 0.0035 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0342 | 0.0399 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0055 | 0.0401 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0035 | 0.0035 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 0.0401 | 0.0401 |
Schistosoma mansoni | alpha-l-fucosidase | 0.1008 | 0.8584 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0307 | 0.0307 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0035 | 0.0041 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0035 | 0.0035 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0342 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0257 | 0.0299 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.1008 | 0.8584 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.1897 | 0.2209 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0307 | 0.0358 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0035 | 0.0041 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 0.0401 | 0.0401 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.1008 | 0.8584 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0035 | 0.0041 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0055 | 0.0401 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0035 | 0.0041 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1172 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0282 | 0.0757 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.0401 | 0.0467 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.1897 | 0.2209 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0282 | 0.0757 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.6 | Displacement of [3H]-dofetilide in human ERG expressed in CHO cells | ChEMBL. | 20951033 |
INH (ADMET) | = 2 uM | Inhibition of CYP2C19 | ChEMBL. | 20951033 |
INH (ADMET) | = 3 uM | Inhibition of CYP2C9 | ChEMBL. | 20951033 |
INH (ADMET) | = 4 uM | Inhibition of CYP2D6 | ChEMBL. | 20951033 |
INH (ADMET) | > 10 uM | Inhibition of CYP1A2 | ChEMBL. | 20951033 |
INH (ADMET) | > 10 uM | Inhibition of CYP3A4 | ChEMBL. | 20951033 |
Ki (functional) | = 5.7 | Antagonistic activity at human alpha1A receptor expressed in rat 1 fibroblast cells assessed as inhibition of calcium level by FLIPR assay | ChEMBL. | 20951033 |
Ki (functional) | = 8.9 | Antagonistic activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay | ChEMBL. | 20951033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.