Detailed information for compound 1265548

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.403 | Formula: C16H16N6OS
  • H donors: 2 H acceptors: 6 LogP: 2.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(CSc2nc(C)cc(n2)C)nc(n1)c1ccccc1O
  • InChi: 1S/C16H16N6OS/c1-9-7-10(2)19-16(18-9)24-8-13-20-14(22-15(17)21-13)11-5-3-4-6-12(11)23/h3-7,23H,8H2,1-2H3,(H2,17,20,21,22)
  • InChiKey: XSYLGJWVMQLGMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha glucosidase 0.0036 0.0234 0.1182
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0061 0.0213
Loa Loa (eye worm) hypothetical protein 0.003 0.0174 0.0955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0333 0.2003
Schistosoma mansoni ap endonuclease 0.002 0.0061 0.0308
Schistosoma mansoni alpha-glucosidase 0.0141 0.1314 0.6643
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0145
Schistosoma mansoni ap endonuclease 0.002 0.0061 0.0308
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0061 0.2229
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1549 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0064 0.0234
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0061 0.1107
Schistosoma mansoni o-methyltransferase 0.006 0.0481 0.243
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0056 0.0179
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0234 0.6643
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0234 0.7015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0321 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0333 0.0333
Echinococcus multilocularis bloom syndrome protein 0.002 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0283
Schistosoma mansoni DNA helicase recq1 0.002 0.0064 0.0325
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0056 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0179
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0061 0.1107
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0321 1
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0283
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0234 0.6643
Toxoplasma gondii exonuclease III APE 0.002 0.0061 0.1578
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0061 0.0061
Mycobacterium tuberculosis Probable methyltransferase 0.006 0.0481 0.0869
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0064 0.2455
Onchocerca volvulus 0.0094 0.0837 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0064 0.0064
Loa Loa (eye worm) O-methyltransferase 0.006 0.0481 0.2972
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0321 1
Schistosoma mansoni alpha-glucosidase 0.0141 0.1314 0.6643
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0174 0.4965
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0174 0.4965
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0234 0.1349
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0234 0.6643
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0056 0.0179
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0321 0.0321
Schistosoma mansoni o-methyltransferase 0.006 0.0481 0.243
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0064 0.1219
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0064 0.0126
Brugia malayi O-methyltransferase family protein 0.006 0.0481 0.2972
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0064 0.1219
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0321 0.1923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0333 0.1685
Brugia malayi hypothetical protein 0.003 0.0174 0.0955
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0283
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0061 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0234 0.6643
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0061 0.0308
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0064 0.1738
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0234 0.6643
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0333 0.0333
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0234 0.6643
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0056 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0174 0.4965
Trypanosoma brucei glucosidase, putative 0.0036 0.0234 0.7015
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0064 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0056 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0321 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1549 0.1549
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0061 0.0213
Loa Loa (eye worm) RecQ helicase 0.002 0.0064 0.0234
Brugia malayi O-methyltransferase family protein 0.006 0.0481 0.2972
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0321 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0234 0.6643
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0321 0.1623
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0061 0.1107
Echinococcus multilocularis GPCR, family 2 0.0019 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0234 0.7015
Echinococcus granulosus GPCR family 2 0.0019 0.0056 0.0283
Schistosoma mansoni hypothetical protein 0.0054 0.0415 0.2099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0056 0.0283
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0029 0.0145
Schistosoma mansoni hypothetical protein 0.0205 0.1978 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0064 0.0325
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0064 0.0126
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0321 0.0321
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0285 0.1685
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0234 0.0234
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0061 0.5
Brugia malayi O-methyltransferase 0.006 0.0481 0.2972
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0321 0.1623
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0234 0.1349
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0321 0.1623
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.006 0.0481 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0234 0.1182
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0482 0.2982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0333 0.1685
Brugia malayi O-methyltransferase family protein 0.006 0.0481 0.2972
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0056 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0234 0.6643
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0333 0.1685
Mycobacterium ulcerans O-methyltransferase 0.0579 0.5852 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0029 0.0029
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0321 0.0321
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0234 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0064 0.0234
Mycobacterium ulcerans methyltransferase 0.006 0.0481 0.0725
Brugia malayi hypothetical protein 0.002 0.0062 0.022
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0234 0.6643
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0234
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0321 0.1623
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0064 0.0126
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0029 0.0029
Entamoeba histolytica recQ family helicase, putative 0.002 0.0064 0.0126
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0234 0.6643
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0234 0.6643
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0333 0.1685
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0064 0.0325
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0064 0.2455
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0064 0.1738
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0285 0.1685
Echinococcus granulosus geminin 0.0205 0.1978 1
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0519 0.523 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1549 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0482 0.2982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0061 0.1107
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1549 0.7834
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0061 0.2229
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0064 0.0234
Schistosoma mansoni hypothetical protein 0.0041 0.0285 0.144
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0064 0.1219
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0174 1
Echinococcus multilocularis geminin 0.0205 0.1978 0.1978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0333 0.1685
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0321 0.1623
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0321 1
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.006 0.0481 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0333 0.2003
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0174 1
Schistosoma mansoni hypothetical protein 0.0205 0.1978 1
Leishmania major hypothetical protein, conserved 0.003 0.0174 0.4965
Loa Loa (eye worm) hypothetical protein 0.006 0.0481 0.2972
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0321 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0064 0.0234
Loa Loa (eye worm) hypothetical protein 0.0045 0.0321 0.1923
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0234 0.7015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0482 0.2982
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0174 0.7078
Schistosoma mansoni o-methyltransferase 0.006 0.0481 0.243
Schistosoma mansoni o-methyltransferase 0.006 0.0481 0.243
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1549 0.1549
Echinococcus granulosus bloom syndrome protein 0.002 0.0064 0.0325
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0174 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0482 0.2982
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0321 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0064 0.0325
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0064 0.0126

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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