Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.0222 | 0.1391 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1391 | 0.0649 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1391 | 0.1391 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0222 | 0.1391 | 0.1386 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.1391 | 0.1391 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0553 | 0.3975 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1391 | 0.0649 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.1391 | 0.1391 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0553 | 0.3975 |
Brugia malayi | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.0461 | 0.3316 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0553 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1315 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.0461 | 0.3316 |
Schistosoma mansoni | acetylcholinesterase | 0.0222 | 0.1391 | 0.0649 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1391 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Onchocerca volvulus | 0.0222 | 0.1391 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Onchocerca volvulus | 0.0222 | 0.1391 | 0.5 | |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.0461 | 0.3316 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0222 | 0.1391 | 0.0649 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0222 | 0.1391 | 0.0649 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1391 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0222 | 0.1391 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0222 | 0.1391 | 0.1386 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0222 | 0.1391 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.1391 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.1391 | 0.5 | |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.1391 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1391 | 0.1391 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.0461 | 0.3316 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.0461 | 0.3316 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0222 | 0.1391 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0222 | 0.1391 | 0.1386 |
Loa Loa (eye worm) | carboxylesterase | 0.1315 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0222 | 0.1391 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0222 | 0.1391 | 1 |
Echinococcus granulosus | neuroligin | 0.0222 | 0.1391 | 0.1386 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0553 | 0.3975 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1391 | 0.0649 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0222 | 0.1391 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0222 | 0.1391 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1391 | 0.1391 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0222 | 0.1391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.0461 | 0.3316 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0222 | 0.1391 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1315 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0222 | 0.1391 | 0.1386 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.