Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cysteine protease | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0249 | 0.1943 | 0.1943 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0476 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0249 | 0.1943 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0476 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Echinococcus multilocularis | cathepsin b | 0.0476 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0476 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0476 | 1 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0366 | 0.6105 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0476 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0476 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0476 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0201 | 0.0218 | 0.0218 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0366 | 0.6105 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0201 | 0.0218 | 0.0218 |
Entamoeba histolytica | cysteine protease, putative | 0.0366 | 0.6105 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0366 | 0.6105 | 0.6105 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.6105 | 0.6019 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0249 | 0.1943 | 0.1943 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0249 | 0.1943 | 0.1943 |
Loa Loa (eye worm) | fibroinase | 0.0366 | 0.6105 | 0.6019 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Plasmodium vivax | vivapain-2 | 0.0366 | 0.6105 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0201 | 0.0218 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Brugia malayi | Cathepsin L-like precursor | 0.0249 | 0.1943 | 0.1943 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0249 | 0.1943 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0366 | 0.6105 | 0.6105 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0366 | 0.6105 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0249 | 0.1943 | 0.1943 |
Loa Loa (eye worm) | cysteine protease | 0.0366 | 0.6105 | 0.6019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0249 | 0.1943 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0366 | 0.6105 | 0.6105 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0366 | 0.6105 | 0.6105 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1943 | 0.1763 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0366 | 0.6105 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0366 | 0.6105 | 0.6105 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Echinococcus granulosus | cathepsin l1 | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0366 | 0.6105 | 0.6105 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0201 | 0.0218 | 0.0356 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0201 | 0.0218 | 0.0356 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0201 | 0.0218 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0366 | 0.6105 | 0.6019 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0366 | 0.6105 | 0.6105 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0366 | 0.6105 | 0.6105 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0249 | 0.1943 | 0.1943 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0366 | 0.6105 | 0.6105 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0366 | 0.6105 | 0.6019 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0366 | 0.6105 | 0.6105 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Onchocerca volvulus | 0.0366 | 0.6105 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0366 | 0.6105 | 1 |
Plasmodium vivax | vivapain-2 | 0.0366 | 0.6105 | 1 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Echinococcus granulosus | cathepsin b | 0.0476 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0249 | 0.1943 | 0.1943 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0366 | 0.6105 | 0.6105 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Leishmania major | cathepsin L-like protease | 0.0366 | 0.6105 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0366 | 0.6105 | 0.6105 |
Toxoplasma gondii | cathepsin CPL | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1943 | 0.1763 |
Giardia lamblia | Cathepsin B precursor | 0.0201 | 0.0218 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0366 | 0.6105 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0366 | 0.6105 | 0.6019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0366 | 0.6105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1943 | 0.1763 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.