TDR Targets

Basic information

Technical information

TDR Targets ID: 1269905
Name: 2-(2,3-dihydro-1,4-benzothiazin-4-yl)-N-(2-me thoxyphenyl)acetamide
MW: 314.402 | Formula: C17H18N2O2S
H donors: 1 H acceptors: 1 LogP: 3.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)CN1CCSc2c1cccc2
InChi: 1S/C17H18N2O2S/c1-21-15-8-4-2-6-13(15)18-17(20)12-19-10-11-22-16-9-5-3-7-14(16)19/h2-9H,10-12H2,1H3,(H,18,20)
InChiKey: VNJUDFMULMWFQE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,3-dihydro-1,4-benzothiazin-4-yl)-N-(2-methoxyphenyl)ethanamide
ZINC03325718
T5306545
MLS000807165
SMR000376309

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	growth factor, augmenter of liver regeneration	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	Erv1 / Alr family protein	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium knowlesi	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Candida albicans	similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania donovani	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Babesia bovis	human hepatopoietin-like protein, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Neospora caninum	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma congolense	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Augmenter of liver regeneration	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hepatopoietin HPO2	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	FAD-linked sulfhydryl oxidase ALR, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	Erv1 / Alr family protein	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Candida albicans	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Theileria parva	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium berghei	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma congolense	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	sulfakinin receptor protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0549	0.0549
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0549	0.0334
Schistosoma mansoni	neuropeptide receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	sex peptide receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0549	0.0334
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0549	0.0334
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0549	0.0334
Brugia malayi	RE15519p	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0549	0.0338
Brugia malayi	G protein-coupled receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0549	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0549	0.0334
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.3537	0.3537
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus granulosus	hypothetical protein	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0549	0.0334
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0549	0.0334
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0549	0.0338
Brugia malayi	Augmenter of liver regeneration	0.0041	0.5609	0.5609
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.5545	0.5545
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0549	0.0334
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0549	0.0334
Schistosoma mansoni	histamine h1 receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0549	0.0334
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0549	0.0334
Echinococcus granulosus	g protein coupled receptor	0.002	0.0549	0.0334
Onchocerca volvulus		0.0033	0.3537	1
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	hypothetical protein	0.002	0.0549	0.0338
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0549	0.0334
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0549	0.0334
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0549	0.0334
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0549	0.0549
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0549	0.0334
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0041	0.5609	0.5
Brugia malayi	G-protein coupled receptor	0.002	0.0549	0.0549
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0549	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0549	0.0334
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0549	0.0334
Echinococcus granulosus	intermediate filament protein	0.0033	0.3537	0.6041
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0549	0.0334
Echinococcus granulosus	lamin	0.0033	0.3537	0.6041
Schistosoma mansoni	amine GPCR	0.002	0.0549	0.0338
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0549	0.0549
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0549	0.0334
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0549	0.0549
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0549	0.0338
Schistosoma mansoni	biogenic amine receptor	0.002	0.0549	0.0338
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0549	0.0338
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0041	0.5609	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	intermediate filament protein	0.0033	0.3537	0.3537
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0549	0.0334
Echinococcus multilocularis	serotonin receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0549	0.0334
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0549	0.0334
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0041	0.5609	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0549	0.0334
Echinococcus granulosus	sex peptide receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0549	0.0549
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0549	0.0549
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0549	0.0334
Brugia malayi	Dopamine receptor	0.002	0.0549	0.0549
Schistosoma mansoni	neuropeptide receptor	0.002	0.0549	0.0338
Brugia malayi	follicle stimulating hormone receptor	0.002	0.0549	0.0549
Echinococcus granulosus	somatostatin receptor	0.002	0.0549	0.0334
Schistosoma mansoni	opsin-like receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0375	0.0375
Schistosoma mansoni	amine GPCR	0.002	0.0549	0.0338
Echinococcus granulosus	g protein coupled receptor	0.002	0.0549	0.0334
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0549	0.0338
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0549	0.0334
Brugia malayi	Serotonin receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	amine GPCR	0.002	0.0549	0.0338
Onchocerca volvulus		0.0033	0.3537	1
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0549	0.0334
Echinococcus granulosus	orexin receptor type 2	0.002	0.0549	0.0334
Schistosoma mansoni	biogenic amine receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0032	0.3397	0.3397
Schistosoma mansoni	hypothetical protein	0.0041	0.5545	1
Echinococcus granulosus	neuropeptide receptor	0.002	0.0549	0.0334
Echinococcus granulosus	lamin dm0	0.0033	0.3537	0.6041
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0549	0.0549
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	1	1
Schistosoma mansoni	lamin	0.0033	0.3537	0.6116
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3537	0.3537
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0041	0.5609	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0549	0.0338
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0041	0.5609	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0375	0.0375
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0549	0.0549
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5545	0.5545
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0549	0.0334
Schistosoma mansoni	hypothetical protein	0.002	0.0549	0.0338
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0549	0.0334
Schistosoma mansoni	hypothetical protein	0.002	0.0549	0.0338
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0041	0.5609	1
Echinococcus multilocularis	musashi	0.0033	0.3537	0.6041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Toxoplasma gondii	Erv1 / Alr family protein	0.0041	0.5609	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus multilocularis	lamin dm0	0.0033	0.3537	0.6041
Leishmania major	hypothetical protein, conserved	0.0041	0.5609	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0549	0.0338
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0549	0.0549
Schistosoma mansoni	neuropeptide receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	G-protein coupled receptor	0.002	0.0549	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	larval opioid receptor	0.002	0.0549	0.0549
Brugia malayi	putative neuropeptide receptor	0.002	0.0549	0.0549
Brugia malayi	AKH receptor	0.002	0.0549	0.0549
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0549	0.0334
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0549	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0549	0.0334
Toxoplasma gondii	Erv1 / Alr family protein	0.0041	0.5609	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0549	0.0338
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0549	0.0334
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0549	0.0338
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0041	0.5609	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0549	0.0338
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0549	0.0549
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0549	0.0549
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	serotonin receptor	0.002	0.0549	0.0334
Schistosoma mansoni	adenoreceptor	0.002	0.0549	0.0338
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0549	0.0334
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0549	0.0334
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0549	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0549	0.0549
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0549	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	Dopamine receptor protein 1	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0549	0.0549
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0549	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	hypothetical protein	0.002	0.0549	0.0338
Schistosoma mansoni	opsin-like receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	amine GPCR	0.002	0.0549	0.0338
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0549	0.0334
Echinococcus granulosus	fmrfamide receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0549	0.0338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	myosin xvIII	0.002	0.0549	0.0338
Echinococcus multilocularis	lamin	0.0033	0.3537	0.6041
Brugia malayi	neuropeptide F receptor	0.002	0.0549	0.0549
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	Serotonin receptor	0.002	0.0549	0.0549
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0549	0.0334
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0549	0.0334
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0549	0.0334
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0549	0.0549
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.3537	0.3537
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0549	0.0334
Schistosoma mansoni	amine GPCR	0.002	0.0549	0.0338
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	1	1
Schistosoma mansoni	biogenic amine receptor	0.002	0.0549	0.0338
Schistosoma mansoni	intermediate filament proteins	0.0033	0.3537	0.6116
Echinococcus granulosus	neuropeptide receptor	0.002	0.0549	0.0334
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus granulosus	g protein coupled receptor	0.002	0.0549	0.0334
Schistosoma mansoni	lamin	0.0033	0.3537	0.6116
Brugia malayi	ORL1-like opioid receptor	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0549	0.0334
Brugia malayi	Melatonin receptor type 1A	0.002	0.0549	0.0549
Schistosoma mansoni	neuropeptide receptor	0.002	0.0549	0.0338
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0375	0.0375
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Brugia malayi	GnHR receptor homolog	0.002	0.0549	0.0549
Echinococcus granulosus	serotonin receptor	0.002	0.0549	0.0334
Brugia malayi	neuropeptide F receptor	0.002	0.0549	0.0549
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0549	0.0338
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.3537	0.3537
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus granulosus	allatostatin A receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hepatopoietin HPO2	0.0041	0.5609	0.5609
Echinococcus multilocularis	somatostatin receptor	0.002	0.0549	0.0334
Brugia malayi	Dopamine receptor protein 2	0.002	0.0549	0.0549
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0041	0.5609	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0549	0.0334
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0549	0.0338
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0549	0.0334
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0549	0.0338
Brugia malayi	hypothetical protein	0.002	0.0549	0.0549
Schistosoma mansoni	opsin-like receptor	0.002	0.0549	0.0338
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0549	0.0334
Loa Loa (eye worm)	hypothetical protein	0.002	0.0549	0.0549
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0549	0.0334
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0375	0.0375

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 1.32 uM	PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]	ChEMBL.	No reference
Potency (functional)	= 0.631 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1379073

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1269905