Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0277 | 0.0023 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0255 | 0.0149 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0255 | 0.0255 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.043 | 0.795 | 0.795 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0255 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0308 | 0.5531 | 0.5531 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0043 | 0.0255 | 1 | |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0277 | 0.0023 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0255 | 0.0255 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0277 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0533 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0255 | 0.0255 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0533 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0255 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0255 | 0.0149 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0255 | 0.0149 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0533 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0277 | 0.0023 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0308 | 0.5531 | 0.5531 |
Brugia malayi | Inositol-1 | 0.0045 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0255 | 0.0149 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.0277 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0533 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0255 | 0.0149 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0255 | 1 |
Onchocerca volvulus | 0.0043 | 0.0255 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Onchocerca volvulus | 0.0043 | 0.0255 | 1 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0533 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0255 | 0.0149 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.0277 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0277 | 0.0023 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0533 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.0277 | 0.0277 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0533 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0414 | 0.7627 | 0.7627 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.043 | 0.795 | 0.795 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.0277 | 0.0277 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0255 | 0.0149 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0533 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.4923 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0255 | 0.0149 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0277 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0533 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0277 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0255 | 0.0255 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0255 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0255 | 0.0149 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0277 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0277 | 0.0277 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.0277 | 0.0277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.