Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | JmjC domain containing protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0111 | 0.1026 | 0.1527 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0443 | 0.5167 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0093 | 0.0806 | 0.1147 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0133 | 0.1302 | 0.1139 |
Brugia malayi | jmjC domain containing protein | 0.0133 | 0.1302 | 0.1139 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0505 | 0.5941 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.009 | 0.0772 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.3599 | 0.3507 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0111 | 0.1026 | 0.1527 |
Schistosoma mansoni | chromobox protein | 0.0191 | 0.2028 | 0.1914 |
Brugia malayi | mbt repeat family protein | 0.0443 | 0.5167 | 1 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0257 | 0.2856 | 0.4682 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0093 | 0.0806 | 0.0674 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0317 | 0.3599 | 0.5962 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0257 | 0.2856 | 0.2754 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0268 | 0.2986 | 0.5001 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0505 | 0.5941 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0373 | 0.4294 | 0.7161 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0373 | 0.4294 | 0.7161 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.5167 | 1 |
Toxoplasma gondii | PLU-1 family protein | 0.0043 | 0.0179 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0075 | 0.0585 | 0.0766 |
Brugia malayi | mbt repeat family protein | 0.0268 | 0.2986 | 0.5001 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0093 | 0.0806 | 0.1147 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0257 | 0.2856 | 0.4682 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.009 | 0.0772 | 0.064 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0257 | 0.2856 | 0.2754 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0373 | 0.4294 | 0.4212 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0093 | 0.0806 | 0.1147 |
Echinococcus multilocularis | chromobox protein 2 | 0.0191 | 0.2028 | 0.3253 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0317 | 0.3599 | 0.5962 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0093 | 0.0806 | 0.1147 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.009 | 0.0772 | 0.1089 |
Echinococcus granulosus | chromobox protein 2 | 0.0191 | 0.2028 | 0.3253 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0037 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.