Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.044 | 0.515 | 0.515 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.044 | 0.515 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.4683 | 0.4966 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.044 | 0.515 | 0.5461 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0787 | 0.9431 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.044 | 0.515 | 0.5461 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.044 | 0.515 | 0.515 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.044 | 0.515 | 0.515 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0787 | 0.9431 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 0.9431 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0787 | 0.9431 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0787 | 0.9431 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.