Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium:solute symporter family protein | 0.1064 | 0.2452 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.1064 | 0.2452 | 0.2452 |
Brugia malayi | GH02984p | 0.1064 | 0.2452 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.1064 | 0.2452 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.2452 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.056 | 0.056 |
Echinococcus granulosus | solute carrier family 5 | 0.4171 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0007 | 0.0007 |
Echinococcus multilocularis | solute carrier family 5 | 0.4171 | 1 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.1064 | 0.2452 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.2452 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.1064 | 0.2452 | 0.2452 |
Schistosoma mansoni | inositol transporter | 0.4171 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.4171 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.4171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.056 | 0.2283 |
Schistosoma mansoni | inositol transporter | 0.4171 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0007 | 0.0007 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.4171 | 1 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.1064 | 0.2452 | 0.2452 |
Brugia malayi | hypothetical protein | 0.0286 | 0.056 | 0.2283 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.1064 | 0.2452 | 0.5 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.1064 | 0.2452 | 0.2452 |
Onchocerca volvulus | 0.1064 | 0.2452 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.056 | 0.056 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.4171 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0007 | 0.003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1122 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.3548 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.