Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0148 | 0.6626 | 0.8454 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.088 | 0.088 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0274 | 0.0274 |
Echinococcus granulosus | lamin | 0.0033 | 0.0274 | 0.0274 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0154 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | glutamate receptor | 0.017 | 0.7838 | 0.7838 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0274 | 0.035 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0209 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0274 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0274 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6626 | 0.6626 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0274 | 0.0274 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0142 | 0.6319 | 0.6929 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0274 | 0.0301 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0142 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6626 | 0.6626 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0274 | 0.0274 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0274 | 0.035 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0274 | 0.0274 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0274 | 0.0274 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0083 | 0.3042 | 0.3335 |
Loa Loa (eye worm) | glutamate receptor | 0.0067 | 0.2162 | 0.2162 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0044 | 0.088 | 0.088 |
Onchocerca volvulus | 0.0033 | 0.0274 | 0.0414 | |
Onchocerca volvulus | 0.0033 | 0.0274 | 0.0414 | |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.017 | 0.7838 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0083 | 0.3042 | 0.3881 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0193 | 0.912 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0142 | 0.6319 | 0.6319 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0044 | 0.088 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0241 | 0.0241 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.6626 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.6626 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0044 | 0.088 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.