Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1525 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0037 | 0.0869 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0102 | 0.519 | 0.519 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0037 | 0.0869 | 0.0869 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1525 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0037 | 0.0869 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.181 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0037 | 0.0869 | 0.0869 |
Echinococcus granulosus | aminopeptidase N | 0.0127 | 0.6792 | 0.6726 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.181 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0037 | 0.0869 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0037 | 0.0869 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.181 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.0037 | 0.0869 | 0.0869 |
Echinococcus multilocularis | aminopeptidase N | 0.0127 | 0.6792 | 0.6792 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9675 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0127 | 0.6792 | 0.6487 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.181 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5923 | 0.5923 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.181 | 0.1069 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.181 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0037 | 0.0869 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0037 | 0.0869 | 1 |
Onchocerca volvulus | 0.0127 | 0.6792 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.4321 | 0.4321 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0037 | 0.0869 | 0.0869 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0037 | 0.0869 | 0.0869 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1525 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0037 | 0.0869 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0037 | 0.0869 | 0.0869 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0037 | 0.0869 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0037 | 0.0869 | 0.0869 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0037 | 0.0869 | 0.0869 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0037 | 0.0869 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0037 | 0.0869 | 0.0869 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.