Detailed information for compound 1281388

Basic information

Technical information
  • TDR Targets ID: 1281388
  • Name: 1-(2-methoxyethyl)-7,7-dimethyl-2-phenyl-2,3, 5,8-tetrahydropyrano[5,4-e]pyrimidine-4-thion e
  • MW: 332.46 | Formula: C18H24N2O2S
  • H donors: 0 H acceptors: 0 LogP: 2.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1C(N=C(C2=C1CC(C)(C)OC2)S)c1ccccc1
  • InChi: 1S/C18H24N2O2S/c1-18(2)11-15-14(12-22-18)17(23)19-16(20(15)9-10-21-3)13-7-5-4-6-8-13/h4-8,16H,9-12H2,1-3H3,(H,19,23)
  • InChiKey: KNCXBUXQXDXGCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-Methoxy-ethyl)-7,7-dimethyl-2-phenyl-1,2,3,5,7,8-hexahydro-pyrano[4,3-d]pyrimidine-4-thione
  • MLS000333588
  • SMR000437770

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.1919 0.1919
Schistosoma mansoni opsin-like receptor 0.0026 0.1919 0.2342
Onchocerca volvulus 0.0026 0.1919 0.2342
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0013 0.0131 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptide s receptor 0.0026 0.1919 0.1919
Schistosoma mansoni adenoreceptor 0.0026 0.1919 0.2342
Echinococcus granulosus g protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptide receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptide receptor 0.0026 0.1919 0.1919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptide receptor 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.003 0.2448 0.2448
Echinococcus granulosus g protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi Sema domain containing protein 0.003 0.2448 0.2448
Onchocerca volvulus 0.0072 0.8193 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus plexin a4 0.0085 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Schistosoma mansoni hypothetical protein 0.003 0.2448 0.2988
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Schistosoma mansoni semaphorin 5-related 0.003 0.2448 0.2988
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.1919 0.1919
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.1919 0.2342
Trichomonas vaginalis STE family protein kinase 0.0069 0.7833 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis plexin a4 0.0085 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni histamine h1 receptor 0.0026 0.1919 0.2342
Schistosoma mansoni plexin 0.0072 0.8193 1
Schistosoma mansoni plexin 0.0042 0.407 0.4967
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.1919 0.2342
Echinococcus multilocularis transcription factor collier 0.0013 0.0131 0.0131
Entamoeba histolytica tyrosin kinase, putative 0.0017 0.0614 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.1919 0.1919
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.1919 0.1919
Echinococcus granulosus allatostatin A receptor 0.0026 0.1919 0.1919
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0069 0.7833 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.1919 0.1919
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) sema domain-containing protein 0.003 0.2448 0.2448
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.1919 0.1919
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.1919 0.2342
Schistosoma mansoni hypothetical protein 0.003 0.2448 0.2988
Schistosoma mansoni amine GPCR 0.0026 0.1919 0.2342
Brugia malayi Dopamine receptor protein 2 0.0026 0.1919 0.1919
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.1919 0.1919
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus granulosus semaphorin 5B 0.003 0.2448 0.2448
Brugia malayi G protein-coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0131
Brugia malayi hypothetical protein 0.003 0.2448 0.2448
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni neuropeptide receptor 0.0026 0.1919 0.2342
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus g protein coupled receptor 0.0026 0.1919 0.1919
Echinococcus granulosus orexin receptor type 2 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0072 0.8193 0.8193
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis serotonin receptor 0.0026 0.1919 0.1919
Brugia malayi neuropeptide F receptor 0.0026 0.1919 0.1919
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.1919 0.1919
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0042 0.407 0.407
Brugia malayi putative neuropeptide receptor 0.0026 0.1919 0.1919
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.1919 0.1919
Brugia malayi Plexin repeat family protein 0.0072 0.8193 0.8193
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.1919 0.1919
Echinococcus granulosus serotonin receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis hypothetical protein 0.003 0.2448 0.2448
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.1919 0.1919
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Echinococcus granulosus sex peptide receptor 0.0026 0.1919 0.1919
Echinococcus granulosus somatostatin receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0131
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.1919 0.1919
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.1919 0.1919
Onchocerca volvulus 0.003 0.2448 0.2988
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.1919 0.1919
Schistosoma mansoni neuropeptide receptor 0.0026 0.1919 0.2342
Echinococcus multilocularis somatostatin receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.1919 0.1919
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.1919 0.1919
Schistosoma mansoni biogenic amine receptor 0.0026 0.1919 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Schistosoma mansoni hypothetical protein 0.0042 0.407 0.4967
Echinococcus multilocularis fmrfamide receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.1919 0.1919
Brugia malayi G-protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.1919 0.1919
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.1919 0.1919
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.1919 0.2342
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0131
Echinococcus granulosus exocyst complex component 2 0.0013 0.0131 0.0131
Onchocerca volvulus 0.0026 0.1919 0.2342
Onchocerca volvulus 0.0026 0.1919 0.2342
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.1919 0.1919
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Echinococcus multilocularis g protein coupled receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis g protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis orexin receptor type 2 0.0026 0.1919 0.1919
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.1919 0.1919
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0026 0.1919 0.2342
Schistosoma mansoni amine GPCR 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.1919 0.2342
Schistosoma mansoni biogenic amine receptor 0.0026 0.1919 0.2342
Brugia malayi sulfakinin receptor protein 0.0026 0.1919 0.1919
Brugia malayi follicle stimulating hormone receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.1919 0.1919
Echinococcus multilocularis allatostatin A receptor 0.0026 0.1919 0.1919
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Loa Loa (eye worm) sema domain-containing protein 0.003 0.2448 0.2448
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.1919 0.1919
Brugia malayi neuropeptide F receptor 0.0026 0.1919 0.1919
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0069 0.7833 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.1919 0.1919
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.1919 0.2342
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.1919 0.2342
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.1919 0.2342
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.1919 0.1919
Echinococcus granulosus g-protein coupled receptor 0.0026 0.1919 0.1919
Brugia malayi ORL1-like opioid receptor 0.0026 0.1919 0.1919
Schistosoma mansoni fibrocystin l 0.0013 0.0131 0.016
Schistosoma mansoni neuropeptide receptor 0.0026 0.1919 0.2342
Brugia malayi Dopamine receptor protein 1 0.0026 0.1919 0.1919
Schistosoma mansoni amine GPCR 0.0026 0.1919 0.2342
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.1919 0.2342
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Brugia malayi larval opioid receptor 0.0026 0.1919 0.1919
Brugia malayi RE15519p 0.0026 0.1919 0.1919
Echinococcus multilocularis serotonin receptor 0.0026 0.1919 0.1919
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.1919 0.1919
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0026 0.1919 0.2342
Onchocerca volvulus 0.0026 0.1919 0.2342
Onchocerca volvulus 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0013 0.0131 0.016
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi Serotonin receptor 0.0026 0.1919 0.1919
Brugia malayi IPT/TIG domain containing protein 0.0013 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0026 0.1919 0.2342
Brugia malayi Dopamine receptor 0.0026 0.1919 0.1919
Schistosoma mansoni amine GPCR 0.0026 0.1919 0.2342
Echinococcus granulosus semaphorin 1A 0.003 0.2448 0.2448
Echinococcus granulosus hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) plexin A 0.0085 1 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.1919 0.1919
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.1919 0.1919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Echinococcus granulosus neuropeptide receptor 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.1919 0.1919
Brugia malayi G-protein coupled receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.1919 0.1919
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Schistosoma mansoni opsin-like receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.1919 0.1919
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.1919 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Brugia malayi Melatonin receptor type 1A 0.0026 0.1919 0.1919
Brugia malayi GnHR receptor homolog 0.0026 0.1919 0.1919
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.1919 0.2342
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.1919 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Schistosoma mansoni amine GPCR 0.0026 0.1919 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Brugia malayi AKH receptor 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.003 0.2448 0.2448
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0131
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.1919 0.1919
Plasmodium vivax serine/threonine protein kinase, putative 0.0069 0.7833 0.5
Echinococcus granulosus transcription factor collier 0.0013 0.0131 0.0131
Echinococcus multilocularis semaphorin 5B 0.003 0.2448 0.2448
Echinococcus multilocularis sex peptide receptor 0.0026 0.1919 0.1919
Brugia malayi Sema domain containing protein 0.003 0.2448 0.2448
Onchocerca volvulus 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.1919 0.1919
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.1919 0.2342
Brugia malayi Serotonin receptor 0.0026 0.1919 0.1919
Trichomonas vaginalis AGC family protein kinase 0.0069 0.7833 1
Echinococcus multilocularis exocyst complex component 2 0.0013 0.0131 0.0131
Onchocerca volvulus 0.0026 0.1919 0.2342
Schistosoma mansoni biogenic amine receptor 0.0026 0.1919 0.2342
Schistosoma mansoni myosin xvIII 0.0026 0.1919 0.2342
Brugia malayi hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.1919 0.2342
Brugia malayi Probable exocyst complex component Sec5 0.0013 0.0131 0.0131
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.1919 0.1919
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.1919 0.1919
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.1919 0.1919
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.1919 0.1919
Leishmania major protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative 0.0069 0.7833 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.1919 0.1919
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.1919 0.1919
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Schistosoma mansoni neuropeptide receptor 0.0026 0.1919 0.2342
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.1919 0.2342
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.1919 0.1919
Entamoeba histolytica protein kinase domain containing protein 0.0017 0.0614 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.1919 0.1919
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Onchocerca volvulus 0.0026 0.1919 0.2342
Onchocerca volvulus 0.0026 0.1919 0.2342
Schistosoma mansoni opsin-like receptor 0.0026 0.1919 0.2342
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.1919 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.1919 0.1919
Schistosoma mansoni hypothetical protein 0.0026 0.1919 0.2342
Echinococcus multilocularis fmrfamide receptor 0.0026 0.1919 0.1919
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 2 0.0069 0.7833 0.5
Brugia malayi DNA-binding protein LAG-1 0.0013 0.0131 0.0131
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.1919 0.2342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.5479 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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