Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0244 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0244 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0244 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0244 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0244 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0244 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0244 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0244 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0244 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0244 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0244 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0244 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0244 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0244 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0244 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0244 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3548 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.