Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0069 | 0.0368 | 0.0373 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0069 | 0.0368 | 0.033 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0218 | 0.1884 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0462 | 0.4367 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.1548 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0058 | 0.0256 | 0.4513 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0626 | 0.603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.3537 | 0.3511 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0626 | 0.603 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 0.5287 | 0.5268 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.1877 |
Leishmania major | hypothetical protein, conserved | 0.0218 | 0.1884 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0069 | 0.0368 | 0.033 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0193 | 0.1626 | 0.2649 |
Echinococcus multilocularis | GPCR, family 2 | 0.0256 | 0.2266 | 0.2464 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0808 | 0.789 | 0.7881 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0116 | 0.0844 | 0.2074 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0256 | 0.2266 | 0.2464 |
Echinococcus granulosus | neuropeptide s receptor | 0.0462 | 0.4367 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0218 | 0.1884 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0256 | 0.2266 | 0.5157 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0218 | 0.1884 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0808 | 0.789 | 0.7883 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0897 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.0592 |
Brugia malayi | hypothetical protein | 0.0141 | 0.1097 | 0.107 |
Brugia malayi | MH1 domain containing protein | 0.0069 | 0.0368 | 0.0339 |
Schistosoma mansoni | smad1 5 8 and | 0.0069 | 0.0368 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0568 | 0.053 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0626 | 0.603 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0626 | 0.603 | 0.6014 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0626 | 0.603 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0808 | 0.789 | 0.7881 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0808 | 0.789 | 0.7883 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0193 | 0.1626 | 0.2649 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0069 | 0.0368 | 0.0373 |
Brugia malayi | Probable ClpP-like protease | 0.0089 | 0.0568 | 0.0539 |
Schistosoma mansoni | Smad4 | 0.0069 | 0.0368 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2266 | 0.2236 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.1046 | 0.2343 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0116 | 0.0844 | 0.2098 |
Schistosoma mansoni | smad1 5 8 and | 0.0069 | 0.0368 | 0.0643 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0069 | 0.0368 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1884 | 0.1852 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0098 | 0.0659 | 0.0694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.1046 | 0.1933 |
Schistosoma mansoni | smad1 5 8 and | 0.0069 | 0.0368 | 0.0643 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.2266 | 0.4255 |
Echinococcus multilocularis | Smad4 | 0.0069 | 0.0368 | 0.0373 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.4361 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0193 | 0.1626 | 0.8604 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0928 | 0.9109 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0256 | 0.2266 | 0.5157 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.1046 | 0.1933 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0014 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0256 | 0.2266 | 0.2243 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0462 | 0.4367 | 0.4777 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0553 | 0.5287 | 0.5273 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.1046 | 0.101 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.1046 | 0.1019 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0218 | 0.1884 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0462 | 0.4367 | 0.4777 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0218 | 0.1884 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0553 | 0.5287 | 1 |
Echinococcus multilocularis | smad | 0.0069 | 0.0368 | 0.0373 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.1046 | 0.1119 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0193 | 0.1626 | 0.8604 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.1046 | 0.101 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.1626 | 0.8604 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0069 | 0.0368 | 0.0643 |
Echinococcus granulosus | smad | 0.0069 | 0.0368 | 0.078 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0626 | 0.603 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0058 | 0.0256 | 0.0522 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0039 | 0.0019 |
Echinococcus granulosus | GPCR family 2 | 0.0256 | 0.2266 | 0.5157 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0807 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0058 | 0.0256 | 0.063 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.0568 | 0.2864 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.1046 | 0.1019 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.1637 | 0.3058 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0218 | 0.1884 | 1 |
Onchocerca volvulus | 0.0626 | 0.603 | 1 | |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0098 | 0.0659 | 0.1452 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0089 | 0.0568 | 0.1023 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0626 | 0.603 | 1 |
Brugia malayi | hypothetical protein | 0.0218 | 0.1884 | 0.186 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0039 | 0.0019 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.124 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0116 | 0.0844 | 0.4361 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0897 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0039 | 0.001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.1046 | 0.1933 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0256 | 0.2266 | 0.2236 |
Loa Loa (eye worm) | nuclear factor I | 0.0038 | 0.0053 | 0.0014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.1046 | 0.1933 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0058 | 0.0256 | 0.063 |
Echinococcus granulosus | Smad4 | 0.0069 | 0.0368 | 0.078 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.1046 | 0.101 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.0882 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0058 | 0.0256 | 0.0249 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0116 | 0.0844 | 0.4361 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.2266 | 0.4255 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0218 | 0.1884 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.5 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0626 | 0.603 | 0.6018 |
Loa Loa (eye worm) | Smad1 | 0.0069 | 0.0368 | 0.033 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.2266 | 0.4255 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0039 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.1637 | 0.3058 |
Brugia malayi | RNA binding protein | 0.0136 | 0.1046 | 0.1019 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0116 | 0.0844 | 0.4361 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0116 | 0.0844 | 0.4361 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0116 | 0.0844 | 0.4361 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0626 | 0.603 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0193 | 0.1626 | 0.8604 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.0568 | 0.2864 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.2266 | 0.4255 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0626 | 0.603 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0816 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0433 | 0.4068 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0659 | 0.1198 |
Brugia malayi | Smad1 | 0.0069 | 0.0368 | 0.0339 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.1046 | 0.1933 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0039 | 0.0011 |
Echinococcus granulosus | geminin | 0.0194 | 0.1637 | 0.3707 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0038 | 0.0053 | 0.0024 |
Schistosoma mansoni | smad | 0.0069 | 0.0368 | 0.0643 |
Brugia malayi | MH1 domain containing protein | 0.0038 | 0.0053 | 0.0024 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0256 | 0.2266 | 0.2464 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0116 | 0.0844 | 0.0897 |
Echinococcus multilocularis | geminin | 0.0194 | 0.1637 | 0.1771 |
Brugia malayi | isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.0816 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0039 | 0.0016 |
Brugia malayi | N-terminal motif family protein | 0.0381 | 0.3537 | 0.3518 |
Brugia malayi | MH2 domain containing protein | 0.0069 | 0.0368 | 0.0339 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0626 | 0.603 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0069 | 0.0368 | 0.0339 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0568 | 0.0882 |
Brugia malayi | MH2 domain containing protein | 0.0069 | 0.0368 | 0.0339 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0626 | 0.603 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0069 | 0.0368 | 0.078 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0116 | 0.0844 | 0.2098 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0256 | 0.2266 | 0.2243 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0089 | 0.0568 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0116 | 0.0844 | 0.4361 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.