Detailed information for compound 1298120

Basic information

Technical information
  • TDR Targets ID: 1298120
  • Name: N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiaz ol-2-yl]-4-nitrobenzamide
  • MW: 390.801 | Formula: C16H11ClN4O4S
  • H donors: 1 H acceptors: 5 LogP: 3.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)OCc1nnc(s1)NC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C16H11ClN4O4S/c17-11-3-7-13(8-4-11)25-9-14-19-20-16(26-14)18-15(22)10-1-5-12(6-2-10)21(23)24/h1-8H,9H2,(H,18,20,22)
  • InChiKey: HNMDQDBTOHJNGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-4-nitro-benzamide
  • ZINC00715506
  • STK158743
  • MLS000544118
  • N-{5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-4-nitrobenzamide
  • SMR000162628

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.281 0.425
Brugia malayi glutathione reductase 0.0046 0.2055 0.3109
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.2055 0.2418
Entamoeba histolytica hypothetical protein 0.0039 0.1524 1
Onchocerca volvulus Alhambra homolog 0.0032 0.0941 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.2718 0.7347
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.7595 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.2104 0.2871
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.7595 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.6611 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0941 0.0738
Schistosoma mansoni DNA polymerase eta 0.0054 0.2718 0.2501
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.2718 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.6676 0.8743
Trypanosoma brucei trypanothione reductase 0.0046 0.2055 0.7274
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.1465 0.3559
Leishmania major hypothetical protein, conserved 0.003 0.0852 0.2319
Loa Loa (eye worm) hypothetical protein 0.003 0.0852 0.1704
Plasmodium vivax glutathione reductase, putative 0.0046 0.2055 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.2055 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0289 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0852 0.2319
Plasmodium falciparum glutathione reductase 0.0046 0.2055 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.1465 0.1861
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0941 0.0738
Loa Loa (eye worm) hypothetical protein 0.0054 0.2721 0.7359
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.6676 0.8743
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0289 0.5
Leishmania major DNA polymerase eta, putative 0.0038 0.1449 0.4775
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.1465 0.1212
Loa Loa (eye worm) hypothetical protein 0.0032 0.0941 0.1973
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.2718 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.281 0.2596
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0941 0.1973
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.6676 0.8743
Brugia malayi hypothetical protein 0.003 0.0852 0.1288
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.1524 0.1954
Echinococcus granulosus dna polymerase eta 0.0054 0.2718 0.3842
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.281 0.7627
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0852 0.2319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.281 0.2596
Entamoeba histolytica hypothetical protein 0.0039 0.1524 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0289 0.5
Leishmania major DNA polymerase eta, putative 0.0054 0.2718 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0941 0.0672
Brugia malayi Bromodomain containing protein 0.0032 0.0941 0.1423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.281 0.3988
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.1465 0.1212
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0289 0.0436
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.6676 0.8743
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0941 0.1031
Leishmania major trypanothione reductase 0.0046 0.2055 0.7274
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.3595 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.1524 0.1272
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0289 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.281 0.3988
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.6611 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.281 0.2596
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.7595 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.2718 0.3842
Echinococcus granulosus jumonji domain containing protein 0.0044 0.1917 0.2575
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.1449 0.4957
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.1917 0.2575
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0852 0.2319
Plasmodium falciparum thioredoxin reductase 0.0046 0.2055 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.6676 0.8743
Toxoplasma gondii thioredoxin reductase 0.0046 0.2055 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.281 0.3988
Brugia malayi Thioredoxin reductase 0.0046 0.2055 0.3109
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0941 0.1031
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.2718 0.411
Brugia malayi jmjC domain containing protein 0.0103 0.6611 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.2104 0.2871
Brugia malayi PHD-finger family protein 0.0032 0.0941 0.1423
Entamoeba histolytica hypothetical protein 0.0039 0.1524 1
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.1465 0.1861
Loa Loa (eye worm) glutathione reductase 0.0046 0.2055 0.5344
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.2055 0.5344
Brugia malayi jmjC domain containing protein 0.0038 0.1465 0.2216
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.1524 0.1954
Mycobacterium tuberculosis Probable reductase 0.0104 0.6676 0.8743
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.7595 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.281 0.3988
Brugia malayi hypothetical protein 0.0039 0.1524 0.2305
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0941 0.0738
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0941 0.0738
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.2055 0.7274
Echinococcus multilocularis peregrin 0.0032 0.0941 0.1031
Schistosoma mansoni jumonji domain containing protein 0.0082 0.4934 0.4783
Giardia lamblia PHD finger protein 15 0.0032 0.0941 1
Entamoeba histolytica hypothetical protein 0.0039 0.1524 1
Schistosoma mansoni hypothetical protein 0.0039 0.1524 0.1272
Echinococcus granulosus peregrin 0.0032 0.0941 0.1031
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1449 0.4775
Schistosoma mansoni hypothetical protein 0.0032 0.0941 0.0672

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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