Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | tumor susceptibility 101 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0367 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Echinococcus multilocularis | tumor susceptibility gene 101 protein | 0.0084 | 0.3671 | 0.392 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.8794 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.8794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1369 | 0.1076 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1369 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3671 | 0.3455 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1369 | 0.1076 |
Echinococcus granulosus | tumor susceptibility gene 101 protein | 0.0084 | 0.3671 | 0.392 |
Entamoeba histolytica | tumor susceptibility gene 101 protein, putative | 0.0057 | 0.1945 | 0.5 |
Trypanosoma brucei | Vps23 core domain containing protein, putative | 0.0027 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | tsg101-related | 0.007 | 0.2768 | 0.2849 |
Schistosoma mansoni | tsg101-related | 0.0057 | 0.1945 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.039 | 0.0063 |
Trichomonas vaginalis | hypothetical protein | 0.0041 | 0.0903 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.8794 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1369 | 0.104 |
Brugia malayi | hypothetical protein | 0.0084 | 0.3671 | 0.3429 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.039 | 0.0024 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0367 | 0.004 |
Echinococcus multilocularis | geminin | 0.0164 | 0.8794 | 1 |
Trypanosoma cruzi | Vps23 core domain containing protein, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.039 | 0.0027 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0367 | 0.004 |
Schistosoma mansoni | tsg101-related | 0.007 | 0.2768 | 0.2849 |
Onchocerca volvulus | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0517 uM | PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation in TR assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3374 uM | PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.