Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0033 | 0.0068 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.0845 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0066 | 0.9606 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0068 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0068 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0068 | 1 |
Treponema pallidum | licC protein (licC) | 0.0409 | 0.1769 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0845 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.2232 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0068 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0068 | 1 |
Onchocerca volvulus | 0.0033 | 0.0068 | 0.5 | |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0409 | 0.1769 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0845 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.2232 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.2232 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0845 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0323 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.