Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.1223 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.1223 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1223 | 1 | 1 |
Echinococcus multilocularis | 0.1208 | 0.9077 | 0.8983 | |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.1223 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1077 | 0.0923 | 0.5 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.1223 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.1077 | 0.0923 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1223 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.1077 | 0.0923 | 0.0923 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.1223 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.1223 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.1223 | 1 | 0.5 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.1223 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.1223 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.1223 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.9077 | 0.9077 |
Leishmania major | protein kinase, putative | 0.1223 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.1223 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1077 | 0.0923 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1223 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.1208 | 0.9077 | 0.8983 |
Entamoeba histolytica | protein kinase, putative | 0.1077 | 0.0923 | 0.5 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.1223 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.1223 | 1 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.1223 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 12.065 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | > 150 um | PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.