Detailed information for compound 130521

Basic information

Technical information
  • TDR Targets ID: 130521
  • Name: 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-N,N-dime thylaniline
  • MW: 363.196 | Formula: C15H14IN3
  • H donors: 0 H acceptors: 1 LogP: 4.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc2n(c1)cc(n2)c1ccc(cc1)N(C)C
  • InChi: 1S/C15H14IN3/c1-18(2)13-6-3-11(4-7-13)14-10-19-9-12(16)5-8-15(19)17-14/h3-10H,1-2H3
  • InChiKey: GUJHUHNUHJMRII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-N,N-dimethyl-aniline
  • 4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline
  • [4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-dimethyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens amyloid beta (A4) precursor protein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
Brugia malayi Amyloid A4 extracellular domain containing protein Get druggable targets OG5_131699 All targets in OG5_131699
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Muscleblind-like protein 0.0156 0.3967 0.3967
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0905 0.1163
Loa Loa (eye worm) hypothetical protein 0.0156 0.3967 0.5095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0964 0.1238
Echinococcus multilocularis thymidylate kinase 0.0154 0.3913 0.9864
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0436 0.1114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0964 0.0964
Onchocerca volvulus Putative thymidylate kinase 0.0154 0.3913 0.5686
Loa Loa (eye worm) hypothetical protein 0.0156 0.3967 0.5095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0905 0.2313
Schistosoma mansoni thymidylate kinase 0.0154 0.3913 1
Echinococcus granulosus thymidylate kinase 0.0154 0.3913 0.9864
Loa Loa (eye worm) hypothetical protein 0.0031 0.0436 0.056
Chlamydia trachomatis thymidylate kinase 0.0154 0.3913 0.5
Mycobacterium ulcerans thymidylate kinase 0.0154 0.3913 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0964 0.0964
Leishmania major hypothetical protein, conserved 0.0061 0.1265 0.2737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0905 0.2313
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0759 0.1351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0436 0.1114
Loa Loa (eye worm) hypothetical protein 0.005 0.0964 0.1238
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0617 0.1555
Schistosoma mansoni hypothetical protein 0.0038 0.0617 0.1576
Loa Loa (eye worm) hypothetical protein 0.0291 0.7786 1
Brugia malayi thymidylate kinase 0.0154 0.3913 0.3913
Trypanosoma cruzi thymidylate kinase, putative 0.0154 0.3913 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0759 0.1351
Brugia malayi Pre-SET motif family protein 0.0031 0.0436 0.0436
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.3653 0.9336
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0061 0.1265 0.2737
Echinococcus granulosus muscleblind protein 0.0156 0.3967 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0436 0.1114
Leishmania major thymidylate kinase-like protein 0.0154 0.3913 1
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0061 0.1265 0.2737
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0154 0.3913 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0436 0.1099
Plasmodium vivax SET domain protein, putative 0.0031 0.0436 0.0463
Plasmodium falciparum thymidylate kinase 0.0154 0.3913 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0617 0.1576
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0154 0.3913 0.5
Entamoeba histolytica Thymidylate kinase, putative 0.0154 0.3913 1
Brugia malayi hypothetical protein 0.0016 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0034 0.0518 0.1323
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.3538 0.8919
Treponema pallidum thymidylate kinase (tmk) 0.0154 0.3913 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0905 0.2282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0518 0.0665
Brugia malayi hypothetical protein 0.0038 0.0617 0.0617
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0659 0.1076
Trichomonas vaginalis set domain proteins, putative 0.0247 0.6552 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0905 0.2282
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0403 0.1017
Trypanosoma cruzi thymidylate kinase, putative 0.0154 0.3913 1
Trypanosoma brucei thymidylate kinase, putative 0.0154 0.3913 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0759 0.1351
Toxoplasma gondii thymidylate kinase 0.0154 0.3913 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0905 0.2282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0343
Loa Loa (eye worm) hypothetical protein 0.0078 0.1762 0.2263
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0617 0.1555
Plasmodium vivax thymidylate kinase, putative 0.0154 0.3913 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0436 0.1099
Schistosoma mansoni hypothetical protein 0.0154 0.3913 1
Onchocerca volvulus 0.0247 0.6552 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0905 0.0905
Echinococcus multilocularis muscleblind protein 1 0.0156 0.3967 1
Brugia malayi Pre-SET motif family protein 0.0217 0.5702 0.5702
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0759 0.1914
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0659 0.0128
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.3653 0.3653
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0436 0.1099
Loa Loa (eye worm) acetyltransferase 0.0145 0.3653 0.4692
Loa Loa (eye worm) thymidylate kinase 0.0154 0.3913 0.5026
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.3653 0.9209
Giardia lamblia CDC8 0.0154 0.3913 1
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0135 0.3363 0.8594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0905 0.2313
Schistosoma mansoni thymidylate kinase 0.0154 0.3913 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.5702 0.7324
Trichomonas vaginalis thymidylate kinase, putative 0.0154 0.3913 0.5445
Echinococcus multilocularis muscleblind protein 0.0156 0.3967 1
Trypanosoma brucei thymidylate kinase, putative 0.0154 0.3913 1
Trichomonas vaginalis thymidylate kinase, putative 0.0154 0.3913 0.5445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0905 0.2282
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0154 0.3913 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0436 0.0463
Loa Loa (eye worm) hypothetical protein 0.0156 0.3976 0.5107
Brugia malayi hypothetical protein 0.0025 0.0267 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0436 0.1114
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0518 0.0518

Activities

Activity type Activity value Assay description Source Reference
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) heart after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) muscle after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) spleen after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) heart after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) muscle after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.01 % Biodistribution of radioactivity in normal mice (ICR) spleen after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.02 % Biodistribution of radioactivity in normal mice (ICR) brain after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.02 % Biodistribution of radioactivity in normal mice (ICR) brain after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) heart after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) muscle after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) spleen after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) heart after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) muscle after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.04 % Biodistribution of radioactivity in normal mice (ICR) spleen after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.05 % Biodistribution of radioactivity in normal mice (ICR) kidney after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.05 % Biodistribution of radioactivity in normal mice (ICR) spleen after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.05 % Biodistribution of radioactivity in normal mice (ICR) kidney after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.05 % Biodistribution of radioactivity in normal mice (ICR) spleen after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.06 % Biodistribution of radioactivity in normal mice (ICR) brain after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.06 % Biodistribution of radioactivity in normal mice (ICR) brain after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) heart after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) muscle after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) spleen after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) heart after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) muscle after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.08 % Biodistribution of radioactivity in normal mice (ICR) spleen after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.09 % Biodistribution of radioactivity in normal mice (ICR) spleen after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.09 % Biodistribution of radioactivity in normal mice (ICR) spleen after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.12 % Biodistribution of radioactivity in normal mice (ICR) heart after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.12 % Biodistribution of radioactivity in normal mice (ICR) muscle after 1 hr of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.12 % Biodistribution of radioactivity in normal mice (ICR) heart after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.12 % Biodistribution of radioactivity in normal mice (ICR) muscle after 1 hr of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.16 % Biodistribution of radioactivity in normal mice (ICR) heart after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.16 % Biodistribution of radioactivity in normal mice (ICR) heart after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.18 % Biodistribution of radioactivity in normal mice blood after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.18 % Biodistribution of radioactivity in normal mice blood after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.21 % Biodistribution of radioactivity in normal mice (ICR) brain after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.21 % Biodistribution of radioactivity in normal mice (ICR) brain after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.22 % Biodistribution of radioactivity in normal mice (ICR) skin after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.22 % Biodistribution of radioactivity in normal mice (ICR) skin after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.25 % Biodistribution of radioactivity in normal mice (ICR) kidney after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.25 % Biodistribution of radioactivity in normal mice (ICR) kidney after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.26 % Biodistribution of radioactivity in normal mice (ICR) brain after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.26 % Biodistribution of radioactivity in normal mice (ICR) brain after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.27 % Biodistribution of radioactivity in normal mice (ICR) lung after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.27 % Biodistribution of radioactivity in normal mice (ICR) lung after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.4 % Biodistribution of radioactivity in normal mice (ICR) spleen after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.4 % Biodistribution of radioactivity in normal mice (ICR) spleen after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.41 % Biodistribution of radioactivity in normal mice (ICR) brain after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.41 % Biodistribution of radioactivity in normal mice (ICR) brain after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.53 % Biodistribution of radioactivity in normal mice (ICR) kidney after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.53 % Biodistribution of radioactivity in normal mice (ICR) kidney after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.61 % Biodistribution of radioactivity in normal mice (ICR) liver after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.61 % Biodistribution of radioactivity in normal mice (ICR) liver after 24 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.79 % Biodistribution of radioactivity in normal mice (ICR) heart after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 0.79 % Biodistribution of radioactivity in normal mice (ICR) heart after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.17 % Biodistribution of radioactivity in normal mice (ICR) kidney after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.17 % Biodistribution of radioactivity in normal mice (ICR) kidney after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.4 % Biodistribution of radioactivity in normal mice blood after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.4 % Biodistribution of radioactivity in normal mice blood after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.46 % Biodistribution of radioactivity in normal mice (ICR) lung after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.46 % Biodistribution of radioactivity in normal mice (ICR) lung after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.51 % Biodistribution of radioactivity in normal mice (ICR) kidney after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.51 % Biodistribution of radioactivity in normal mice (ICR) kidney after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.54 % Biodistribution of radioactivity in normal mice (ICR) liver after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.54 % Biodistribution of radioactivity in normal mice (ICR) liver after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.82 % Biodistribution of radioactivity in normal mice blood after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 1.82 % Biodistribution of radioactivity in normal mice blood after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.19 % Biodistribution of radioactivity in normal mice (ICR) skin after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.19 % Biodistribution of radioactivity in normal mice (ICR) skin after 6 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.44 % Biodistribution of radioactivity in normal mice blood after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.44 % Biodistribution of radioactivity in normal mice blood after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.5 % Biodistribution of radioactivity in normal mice blood after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.5 % Biodistribution of radioactivity in normal mice blood after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.88 % Biodistribution of radioactivity in normal mice (ICR) brain after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.88 % Biodistribution of radioactivity in normal mice (ICR) brain after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.9 % Biodistribution of radioactivity in normal mice (ICR) liver after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.9 % Biodistribution of radioactivity in normal mice (ICR) liver after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.96 % Biodistribution of radioactivity in normal mice (ICR) lung after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 2.96 % Biodistribution of radioactivity in normal mice (ICR) lung after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 3.14 % Biodistribution of radioactivity in normal mice (ICR) skin after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 3.14 % Biodistribution of radioactivity in normal mice (ICR) skin after 2 hours of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.28 % Biodistribution of radioactivity in normal mice (ICR) skin after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.28 % Biodistribution of radioactivity in normal mice (ICR) skin after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.69 % Biodistribution of radioactivity in normal mice (ICR) skin after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.69 % Biodistribution of radioactivity in normal mice (ICR) skin after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.75 % Biodistribution of radioactivity in normal mice (ICR) kidney after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 4.75 % Biodistribution of radioactivity in normal mice (ICR) kidney after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.03 % Biodistribution of radioactivity in normal mice (ICR) lung after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.03 % Biodistribution of radioactivity in normal mice (ICR) lung after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.72 % Biodistribution of radioactivity in normal mice (ICR) skin after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.72 % Biodistribution of radioactivity in normal mice (ICR) skin after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.88 % Biodistribution of radioactivity in normal mice (ICR) liver after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 5.88 % Biodistribution of radioactivity in normal mice (ICR) liver after 1 hour of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.08 % Biodistribution of radioactivity in normal mice (ICR) muscle after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.08 % Biodistribution of radioactivity in normal mice (ICR) lung after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.08 % Biodistribution of radioactivity in normal mice (ICR) muscle after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.08 % Biodistribution of radioactivity in normal mice (ICR) lung after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.32 % Biodistribution of radioactivity in normal mice (ICR) liver after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.32 % Biodistribution of radioactivity in normal mice (ICR) liver after 30 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.41 % Biodistribution of radioactivity in normal mice blood after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 6.41 % Biodistribution of radioactivity in normal mice blood after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 13.8 % Biodistribution of radioactivity in normal mice (ICR) muscle after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 13.8 % Biodistribution of radioactivity in normal mice (ICR) lung after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 13.8 % Biodistribution of radioactivity in normal mice (ICR) muscle after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 13.8 % Biodistribution of radioactivity in normal mice (ICR) lung after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 20.9 % Biodistribution of radioactivity in normal mice (ICR) liver after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Dose/organ (ADMET) = 20.9 % Biodistribution of radioactivity in normal mice (ICR) liver after 2 minutes of intravenous injection of [125I]-16(IMPY) ChEMBL. 12519062
Ki (binding) = 3.05 nM Inhibition of [125I]IMPY binding to amyloid beta (1 to 42) aggregates (unknown origin) by gamma counting ChEMBL. No reference
Ki (binding) = 5 nM Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL ChEMBL. 16640346
Ki (binding) = 5 nM Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL ChEMBL. 16640346
Ki (binding) = 8.9 nM Binding affinity to human beta amyloid plaque in alzheimer's disease patient brain ChEMBL. 17722900
Ki (binding) = 8.95 nM Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue ChEMBL. 18078311
Ki (binding) = 10.3 nM Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue ChEMBL. 16574411
Ki (binding) = 10.3 nM Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue ChEMBL. 16574411
Ki (binding) = 15 nM Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregates ChEMBL. 12519062
Ki (binding) = 15 nM Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregates ChEMBL. 12519062
Ki (binding) = 45.6 nM Displacement of [125I]DMIC from Amyloid beta (1 to 42) after 3 hrs by gamma counting ChEMBL. 21145738
Ki (binding) > 5000 nM Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uL ChEMBL. 16640346
Ki (binding) > 5000 nM Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uL ChEMBL. 16640346
Log D = 3.58 Lipophilicity, log D of the compound at pH 7.4 ChEMBL. 18078311
LogP = 3.58 Lipophilicity, Log P of the compound ChEMBL. 16574411

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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