Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0413 | 0.0706 |
Mycobacterium tuberculosis | Long conserved protein | 0.0295 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0295 | 1 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.5853 | 0.5853 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1313 | 0.1313 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4676 | 0.7989 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1313 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6732 | 0.6732 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0413 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0802 | 0.0802 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4539 | 0.4539 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0295 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4539 | 0.7755 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.0295 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.5853 | 0.5853 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.5853 | 0.5853 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0295 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0295 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4539 | 0.7755 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0413 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4676 | 0.7989 |
Brugia malayi | hypothetical protein | 0.002 | 0.0022 | 0.0022 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0295 | 1 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0802 | 0.137 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0295 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0295 | 1 | 1 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0295 | 1 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0295 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0413 | 0.0413 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0295 | 1 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0295 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.6732 | 0.6732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5853 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6732 | 0.6732 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1313 | 0.2243 |
Mycobacterium ulcerans | hypothetical protein | 0.0295 | 1 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.5853 | 0.5853 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1493 | 0.1493 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0413 | 0.5 |
Brugia malayi | hypothetical protein | 0.0148 | 0.4676 | 0.4676 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0295 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1493 | 0.2551 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0413 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0413 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1313 | 0.1313 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6732 | 0.6732 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1493 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5853 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1313 | 0.1313 |
Giardia lamblia | Hypothetical protein | 0.0295 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1493 | 0.1493 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1313 | 0.1313 |
Onchocerca volvulus | 0.0295 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 79.37 um | PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 631, 731, 1032, 1300 ] | ChEMBL. | No reference |
EC50 (functional) | > 79.37 um | PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 1032, 631, 731 ] | ChEMBL. | No reference |
EC50 (functional) | > 79.37 um | PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 1032, 631, 731 ] | ChEMBL. | No reference |
EC50 (functional) | > 260 uM | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] | ChEMBL. | No reference |
Potency (binding) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.