Detailed information for compound 1310031

Basic information

Technical information
  • TDR Targets ID: 1310031
  • Name: 1-cyclohexyl-5-oxo-N-(pyridin-2-ylmethyl)pyrr olidine-2-carboxamide
  • MW: 301.383 | Formula: C17H23N3O2
  • H donors: 1 H acceptors: 3 LogP: 1.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCC(=O)N1C1CCCCC1)NCc1ccccn1
  • InChi: 1S/C17H23N3O2/c21-16-10-9-15(20(16)14-7-2-1-3-8-14)17(22)19-12-13-6-4-5-11-18-13/h4-6,11,14-15H,1-3,7-10,12H2,(H,19,22)
  • InChiKey: DEOCHMDPSILWAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclohexyl-5-oxo-N-(2-pyridylmethyl)pyrrolidine-2-carboxamide
  • 1-cyclohexyl-5-oxo-N-(2-pyridylmethyl)-2-pyrrolidinecarboxamide
  • 1-cyclohexyl-5-keto-N-(2-pyridylmethyl)pyrrolidine-2-carboxamide
  • MLS000522825
  • SMR000128091
  • EU-0097867

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2838 1 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.016 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.016 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.016 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.016 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.016 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.016 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.016 0.5
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.016 0.5
Mycobacterium ulcerans TetR family transcriptional regulator 0.2838 1 0.5
Trypanosoma brucei protein kinase, putative 0.0049 0.016 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.016 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.016 0.5
Brugia malayi MAP kinase sur-1 0.0049 0.016 0.5
Mycobacterium ulcerans transcriptional regulator 0.2838 1 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.016 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.016 0.5
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.016 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.016 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.016 0.5
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.016 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.016 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.016 0.5
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.016 0.5
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2838 1 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.