Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.016 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.016 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.016 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.016 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0049 | 0.016 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.016 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.016 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.016 | 0.5 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.2838 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.016 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.016 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.016 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.016 | 0.5 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.2838 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.016 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.016 | 0.5 |
Mycobacterium ulcerans | transcriptional regulator | 0.2838 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.016 | 0.5 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.2838 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0049 | 0.016 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.016 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.016 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.016 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.016 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.016 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.