TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.219 | Formula: C15H15Cl2N5O
H donors: 2 H acceptors: 4 LogP: 4.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1cc(O)n2c(n1)nc(n2)NCc1c(Cl)cccc1Cl
InChi: 1S/C15H15Cl2N5O/c1-2-4-9-7-13(23)22-15(19-9)20-14(21-22)18-8-10-11(16)5-3-6-12(10)17/h3,5-7,23H,2,4,8H2,1H3,(H,18,21)
InChiKey: FHZOSYAJYRBVKM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0121	0.4767	0.475
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0121	0.4767	0.4767
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.4767	0.4671
Echinococcus granulosus	neuropeptide receptor A26	0.0121	0.4767	0.4671
Schistosoma mansoni	biogenic amine receptor	0.0121	0.4767	0.475
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0121	0.4767	0.4671
Echinococcus granulosus	g protein coupled receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0121	0.4767	0.475
Echinococcus granulosus	voltage gated potassium channel	0.0024	0.0514	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Loa Loa (eye worm)	TYRA-2 protein	0.0121	0.4767	0.4767
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0121	0.4767	0.4671
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0121	0.4767	0.4671
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Leishmania major	cytochrome p450-like protein	0.0012	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	allatostatin A receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.4767	0.4671
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0024	0.0514	0.0342
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.4767	0.4671
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.1717	0.5
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.2868	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0121	0.4767	0.475
Schistosoma mansoni	ceramide glucosyltransferase	0.024	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0179	0.0147
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0016	0.0179	0.0179
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0121	0.4767	0.4767
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.4767	0.4671
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.4767	0.4671
Echinococcus granulosus	serotonin receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Echinococcus multilocularis	voltage gated potassium channel	0.0024	0.0514	0.0342
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0121	0.4767	0.475
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.4767	0.475
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.4767	0.475
Brugia malayi	Dopamine receptor protein 1	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	ORL1-like opioid receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	opsin-like receptor	0.0121	0.4767	0.475
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0121	0.4767	0.4671
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.1717	0.572
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.4767	0.4671
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0121	0.4767	0.4767
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.7144	0.7135
Schistosoma mansoni	neuropeptide receptor	0.0121	0.4767	0.475
Brugia malayi	follicle stimulating hormone receptor	0.0121	0.4767	0.4767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	serotonin receptor	0.0121	0.4767	0.4671
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0121	0.4767	0.475
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0179	0.0147
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.4767	0.475
Schistosoma mansoni	hypothetical protein	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0514	0.0514
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0024	0.0514	0.0342
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.0179	0.0147
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	orexin receptor type 2	0.0121	0.4767	0.4671
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1883	0.1735
Brugia malayi	neuropeptide F receptor	0.0121	0.4767	0.4767
Brugia malayi	Dopamine receptor protein 2	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Trypanosoma brucei	cytochrome P450, putative	0.0012	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.4767	0.4767
Brugia malayi	G protein-coupled receptor	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	G-protein coupled receptor	0.0121	0.4767	0.4767
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0016	0.0179	0.0179
Echinococcus granulosus	g protein coupled receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.3444	0.3423
Echinococcus multilocularis	serotonin receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.6929	0.6873
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1883	0.1735
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Brugia malayi	Melatonin receptor type 1A	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0121	0.4767	0.4767
Schistosoma mansoni	myosin xvIII	0.0121	0.4767	0.475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0514	0.0484
Schistosoma mansoni	amine GPCR	0.0121	0.4767	0.475
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.4767	0.4671
Brugia malayi	G protein-coupled receptor F59B2.13	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.4767	0.4671
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.4767	0.475
Echinococcus multilocularis	sex peptide receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.1717	0.5
Brugia malayi	larval opioid receptor	0.0121	0.4767	0.4767
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.4767	0.475
Brugia malayi	Serotonin receptor	0.0121	0.4767	0.4767
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	histamine h1 receptor	0.0121	0.4767	0.475
Echinococcus granulosus	g-protein coupled receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	neuropeptide receptor	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	GnHR receptor homolog	0.0121	0.4767	0.4767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Schistosoma mansoni	biogenic amine receptor	0.0121	0.4767	0.475
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.1717	0.1566
Brugia malayi	RE15519p	0.0121	0.4767	0.4767
Schistosoma mansoni	hypothetical protein	0.0121	0.4767	0.475
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0083	0.3109	0.3109
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0121	0.4767	0.4671
Echinococcus multilocularis	dro:myosuppressin receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.4767	0.4767
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0083	0.3109	0.2983
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0121	0.4767	0.4671
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	biogenic amine receptor	0.0121	0.4767	0.475
Brugia malayi	AKH receptor	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	dro:myosuppressin receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.3444	0.3423
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0121	0.4767	0.4767
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1883	0.1883
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0121	0.4767	0.4671
Schistosoma mansoni	voltage-gated potassium channel	0.0016	0.0179	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	putative neuropeptide receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	neuropeptide receptor	0.0121	0.4767	0.475
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.4767	0.4671
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.1717	0.572
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0121	0.4767	0.475
Brugia malayi	putative neuropeptide receptor NPR1	0.0121	0.4767	0.4767
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	G protein coupled receptor 139	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	adenoreceptor	0.0121	0.4767	0.475
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0121	0.4767	0.4767
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0514	0.0484
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.4767	0.4671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0016	0.0179	0.0179
Schistosoma mansoni	amine GPCR	0.0121	0.4767	0.475
Loa Loa (eye worm)	ceramide glucosyltransferase	0.024	1	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	7TM GPCR rhodopsin	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2626	0.2626
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0121	0.4767	0.4767
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	somatostatin receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.0179	0.0147
Schistosoma mansoni	amine GPCR	0.0121	0.4767	0.475
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1883	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0179	0.0179
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.1529	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1883	0.1735
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0121	0.4767	0.475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0121	0.4767	0.475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1883	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0121	0.4767	0.475
Echinococcus granulosus	somatostatin receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.024	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	ceramide glucosyltransferase	0.024	1	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus granulosus	neuropeptide FF receptor 2	0.0121	0.4767	0.4671
Schistosoma mansoni	hypothetical protein	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	amine GPCR	0.0121	0.4767	0.475
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.1529	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0083	0.3109	0.2983
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.7144	0.7092
Echinococcus multilocularis	ceramide glucosyltransferase	0.024	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0121	0.4767	0.4767
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.1717	0.5
Schistosoma mansoni	ceramide glucosyltransferase	0.024	1	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	neuropeptide f receptor 76f	0.0121	0.4767	0.475
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Echinococcus multilocularis	g-protein coupled receptor	0.0121	0.4767	0.4671
Giardia lamblia	Ceramide glucosyltransferase	0.0109	0.4236	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.7144	0.7144
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	sex peptide receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.4767	0.4671
Echinococcus granulosus	neuropeptide receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0121	0.4767	0.4671
Echinococcus granulosus	fmrfamide receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1883	0.1856
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0121	0.4767	0.4767
Schistosoma mansoni	growth hormone secretagogue receptor	0.0121	0.4767	0.475
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.4767	0.475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Brugia malayi	neuropeptide F receptor	0.0121	0.4767	0.4767
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.4767	0.4671
Echinococcus granulosus	g protein coupled receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptide s receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.4767	0.4767
Brugia malayi	Serotonin receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.4767	0.475
Echinococcus granulosus	neuropeptide s receptor	0.0121	0.4767	0.4671
Echinococcus granulosus	orexin receptor type 2	0.0121	0.4767	0.4671
Brugia malayi	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	opsin-like receptor	0.0121	0.4767	0.475
Loa Loa (eye worm)	melatonin receptor type 1A	0.0121	0.4767	0.4767
Brugia malayi	sulfakinin receptor protein	0.0121	0.4767	0.4767
Echinococcus granulosus	7tm_1 domain containing protein	0.0121	0.4767	0.4671
Loa Loa (eye worm)	acetyltransferase	0.0175	0.7144	0.7144
Echinococcus granulosus	hypothetical protein	0.0121	0.4767	0.4671
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0121	0.4767	0.4671
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.4767	0.475
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1883	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0179	0.0147
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1883	0.1735
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	G protein coupled receptor 139	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	neuropeptide receptor A26	0.0121	0.4767	0.4671
Schistosoma mansoni	amine GPCR	0.0121	0.4767	0.475
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.4767	0.4671
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0083	0.3109	0.3109
Brugia malayi	G-protein coupled receptor	0.0121	0.4767	0.4767
Schistosoma mansoni	neuropeptide receptor	0.0121	0.4767	0.475
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0121	0.4767	0.4671
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.4767	0.4671
Schistosoma mansoni	opsin-like receptor	0.0121	0.4767	0.475
Brugia malayi	Dopamine receptor	0.0121	0.4767	0.4767
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0024	0.0514	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4767	0.4767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.4767	0.4671

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5623 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1420281

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1311639