Detailed information for compound 131280

Basic information

Technical information
  • TDR Targets ID: 131280
  • Name: 1H-perimidin-2-amine
  • MW: 183.209 | Formula: C11H9N3
  • H donors: 2 H acceptors: 0 LogP: 1.49 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2cccc3c2c([nH]1)ccc3
  • InChi: 1S/C11H9N3/c12-11-13-8-5-1-3-7-4-2-6-9(14-11)10(7)8/h1-6H,(H3,12,13,14)
  • InChiKey: UNDUSVBXIVZGOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1H-perimidin-2-ylamine
  • 2-aminoperimidine
  • 28832-64-6
  • 331717-46-5
  • ZINC00066099
  • Aminoperimidine
  • EINECS 249-264-0
  • Perimidine, 2-amino-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3B References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B References
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Escherichia coli sodium-proton antiporter Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1006 0.914 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0759 0.6355 1
Brugia malayi hypothetical protein 0.0358 0.1828 0.2131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0759 0.6355 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0358 0.1828 0.2131
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0358 0.1828 0.2131
Onchocerca volvulus Protein ultraspiracle homolog 0.0759 0.6355 1
Loa Loa (eye worm) nuclear hormone receptor 0.0358 0.1828 0.2459
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0759 0.6355 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.2806 0.3831
Echinococcus multilocularis thyroid hormone receptor alpha 0.0759 0.6355 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0378 0.205 0.3226
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0759 0.6355 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0759 0.6355 1
Schistosoma mansoni nuclear receptor 0.0358 0.1828 0.1426
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0358 0.1828 0.2877
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0358 0.1828 0.1561
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0358 0.1828 0.2877
Brugia malayi Nuclear hormone receptor E75 0.0358 0.1828 0.2131
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0249 0.0602 0.0417
Schistosoma mansoni RAR-like nuclear receptor 0.0759 0.6355 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0759 0.6355 1
Brugia malayi nuclear receptor NHR-88 0.0759 0.6355 1
Onchocerca volvulus 0.0358 0.1828 0.1561
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Brugia malayi nuclear receptor RXR 0.0358 0.1828 0.2131
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0759 0.6355 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0358 0.1828 0.1561
Brugia malayi hypothetical protein 0.0401 0.2313 0.2974
Schistosoma mansoni nuclear hormone receptor 0.0759 0.6355 1
Schistosoma mansoni thyroid hormone receptor 0.0759 0.6355 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0759 0.6355 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0759 0.6355 1
Brugia malayi nuclear hormone receptor 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0401 0.2313 0.3639
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.2806 0.5
Loa Loa (eye worm) hypothetical protein 0.0445 0.2806 0.4088
Brugia malayi orphan nuclear receptor NR2E1 0.0358 0.1828 0.2131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0759 0.6355 1
Schistosoma mansoni nuclear receptor 0.0358 0.1828 0.1426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0759 0.6355 1
Onchocerca volvulus Bile acid receptor homolog 0.0759 0.6355 1
Brugia malayi Steroid receptor seven-up type 2 0.0759 0.6355 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0378 0.205 0.3226
Loa Loa (eye worm) hypothetical protein 0.0401 0.2313 0.3267
Brugia malayi nuclear receptor RXR 0.0401 0.2313 0.2974
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0759 0.6355 1
Trichomonas vaginalis set domain proteins, putative 0.0284 0.0991 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0378 0.205 0.1847
Loa Loa (eye worm) nuclear receptor NHR-67 0.0358 0.1828 0.2459
Echinococcus granulosus Nuclear hormone receptor HR96 0.0358 0.1828 0.2877
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0358 0.1828 0.2877
Brugia malayi nuclear hormone receptor family member nhr-6 0.0358 0.1828 0.2131
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0759 0.6355 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0759 0.6355 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0759 0.6355 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0759 0.6355 1
Brugia malayi ecdysteroid receptor 0.0759 0.6355 1
Brugia malayi nuclear hormone receptor 0.0358 0.1828 0.2131
Brugia malayi conserved hypotetical protein 0.0358 0.1828 0.2131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0358 0.1828 0.2877
Loa Loa (eye worm) hypothetical protein 0.0401 0.2313 0.3267
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0401 0.2313 0.3267
Brugia malayi nuclear receptor NHR-88 0.0358 0.1828 0.2131
Brugia malayi ecdysone receptor 0.0358 0.1828 0.2131
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0759 0.6355 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0358 0.1828 0.2877
Brugia malayi Nuclear hormone receptor-like 1 0.0401 0.2313 0.2974
Brugia malayi Nuclear hormone receptor-like 1 0.0759 0.6355 1
Brugia malayi Nuclear hormone receptor E75 0.0358 0.1828 0.2131
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0759 0.6355 1
Brugia malayi steroid hormone receptor 0.0759 0.6355 1
Echinococcus granulosus FTZ F1 alpha 0.0759 0.6355 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0759 0.6355 1
Onchocerca volvulus 0.0759 0.6355 1
Schistosoma mansoni nuclear hormone receptor 0.0358 0.1828 0.1426
Loa Loa (eye worm) hypothetical protein 0.0401 0.2313 0.3267
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.2806 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0401 0.2313 0.3639
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1082 1 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0759 0.6355 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0401 0.2313 0.2344
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0759 0.6355 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Brugia malayi tailless protein 0.0358 0.1828 0.2131
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0358 0.1828 0.1426
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0759 0.6355 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0358 0.1828 0.2877
Schistosoma mansoni coup transcription factor 0.0759 0.6355 1
Echinococcus multilocularis FTZ F1 alpha 0.0759 0.6355 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0759 0.6355 1
Brugia malayi hypothetical protein 0.0401 0.2313 0.2974
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0759 0.6355 1
Brugia malayi Nuclear hormone receptor-like 1 0.0401 0.2313 0.2974
Echinococcus granulosus nuclear receptor nhr 48 0.0358 0.1828 0.2877
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Brugia malayi nuclear receptor NHR-67 0.0358 0.1828 0.2131
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Schistosoma mansoni thyroid hormone receptor 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Brugia malayi hypothetical protein 0.0358 0.1828 0.2131
Loa Loa (eye worm) steroid hormone receptor 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0759 0.6355 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0759 0.6355 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0401 0.2313 0.3267
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0358 0.1828 0.2459
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Echinococcus granulosus ecdysone induced protein 78C 0.0759 0.6355 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0759 0.6355 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0759 0.6355 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0358 0.1828 0.2877
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0759 0.6355 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0358 0.1828 0.2877
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0759 0.6355 1
Schistosoma mansoni retinoic acid receptor RXR 0.0759 0.6355 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0759 0.6355 1
Schistosoma mansoni nuclear receptor nhr-48 0.0358 0.1828 0.1426
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0759 0.6355 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0358 0.1828 0.2877
Loa Loa (eye worm) DR-78 0.0358 0.1828 0.2459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0759 0.6355 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0759 0.6355 1
Loa Loa (eye worm) hypothetical protein 0.0401 0.2313 0.3267
Schistosoma mansoni nuclear hormone receptor 0.0358 0.1828 0.1426
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0358 0.1828 0.1426
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0759 0.6355 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0759 0.6355 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0759 0.6355 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.2806 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0401 0.2313 0.2344
Echinococcus granulosus thyroid hormone receptor alpha 0.0358 0.1828 0.2877
Onchocerca volvulus 0.0358 0.1828 0.1561
Schistosoma mansoni zinc finger protein 0.0358 0.1828 0.1426
Loa Loa (eye worm) hypothetical protein 0.0358 0.1828 0.2459

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates ChEMBL. 1975275
IC50 (binding) > 10000 nM In vitro inhibitory activity against [3H]-(+)-MK-801 binding to PCP receptor in guinea pig brain membrane homogenates ChEMBL. 1975275
IC50 (binding) > 10000 nM In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates ChEMBL. 1975275
IC50 (binding) > 10000 nM In vitro inhibitory activity against [3H]-(+)-MK-801 binding to PCP receptor in guinea pig brain membrane homogenates ChEMBL. 1975275
IC50 (binding) = 1.7 uM Antiporter activity in Escherichia coli K12 wild type EcNhaA assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay ChEMBL. 17981808
IC50 (binding) = 2.2 uM Antiporter activity in Escherichia coli K12 wild type EcNhaA assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay ChEMBL. 17981808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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