Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7379 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4439 | 0.5 | |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7379 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4722 | 0.6015 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.0453 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4722 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4439 | 0.5381 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0191 | 0.0127 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0711 | 0.0651 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.0453 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4439 | 0.5396 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4439 | 0.4403 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7379 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8876 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.