Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | 0.0012 | 0.354 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.354 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.354 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.354 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.354 | 0.354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0501 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.