Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.02 | 0.1243 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0066 | 0.0397 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0496 | 0.2957 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.02 | 0.1243 | 0.1184 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.6409 | 0.6409 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.0496 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0496 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Brugia malayi | Fli-1 protein | 0.0265 | 0.1676 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Schistosoma mansoni | amine oxidase | 0.02 | 0.1243 | 0.1243 |
Onchocerca volvulus | 0.02 | 0.1243 | 0.5 | |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.0496 | 0.0572 |
Plasmodium vivax | hypothetical protein, conserved | 0.02 | 0.1243 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.02 | 0.1243 | 0.1367 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1521 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.02 | 0.1243 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.02 | 0.1243 | 0.1184 |
Brugia malayi | SWIRM domain containing protein | 0.02 | 0.1243 | 0.7413 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1321 | 0.8673 | 1 |
Schistosoma mansoni | amine oxidase | 0.02 | 0.1243 | 0.1243 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0066 | 0.5 |
Brugia malayi | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.0496 | 0.0496 |
Echinococcus multilocularis | 0.02 | 0.1243 | 0.1243 | |
Schistosoma mansoni | ets-related | 0.0265 | 0.1676 | 0.1676 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.02 | 0.1243 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.02 | 0.1243 | 0.1433 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0066 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1521 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0066 | 0.0077 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 0.1676 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1521 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0066 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.02 | 0.1243 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.02 | 0.1243 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.02 | 0.1243 | 0.1433 |
Mycobacterium ulcerans | monoamine oxidase | 0.02 | 0.1243 | 0.1184 |
Leishmania major | UDP-galactopyranose mutase | 0.02 | 0.1243 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0066 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.02 | 0.1243 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.02 | 0.1243 | 0.7413 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1521 | 1 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.02 | 0.1243 | 0.1367 |
Mycobacterium ulcerans | oxidoreductase | 0.02 | 0.1243 | 0.1184 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.02 | 0.1243 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.02 | 0.1243 | 0.1243 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.02 | 0.1243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0412 | 0.2456 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0066 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.02 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.0496 | 0.0496 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.02 | 0.1243 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1243 | 0.7413 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0066 | 0.0066 |
Plasmodium vivax | hypothetical protein, conserved | 0.02 | 0.1243 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0066 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.02 | 0.1243 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0066 | 0.0397 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1321 | 0.8673 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0828 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.2592 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 0.9466 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.