Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | 0.1555 | 0.8275 | 0.8137 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Plasmodium falciparum | carbonic anhydrase | 0.0699 | 0.3502 | 0.5 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0192 | 0.0671 | 0.0811 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1555 | 0.8275 | 0.8248 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Brugia malayi | Presenilin family protein | 0.0204 | 0.0741 | 0.0896 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0696 | 0.348 | 0.4689 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2803 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1169 | 0.612 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2198 |
Echinococcus granulosus | carbonic anhydrase II | 0.1555 | 0.8275 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Brugia malayi | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.0699 | 0.3502 | 0.3399 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Schistosoma mansoni | carbonic anhydrase | 0.0699 | 0.3502 | 0.3399 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1864 | 1 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1658 | 0.8847 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0192 | 0.0671 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1555 | 0.8275 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1555 | 0.8275 | 0.8248 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1555 | 0.8275 | 1 |
Echinococcus granulosus | presenilin | 0.0204 | 0.0741 | 0.072 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0487 | 0.232 | 0.2665 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Echinococcus multilocularis | presenilin | 0.0204 | 0.0741 | 0.072 |
Toxoplasma gondii | hypothetical protein | 0.0699 | 0.3502 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0962 | 0.4967 | 0.7679 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1555 | 0.8275 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1555 | 0.8275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Brugia malayi | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1658 | 0.8847 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0699 | 0.3502 | 0.4232 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0487 | 0.232 | 0.2665 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2803 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1864 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0699 | 0.3502 | 0.4232 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0192 | 0.0671 | 0.0634 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0192 | 0.0671 | 0.0634 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1864 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1555 | 0.8275 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0204 | 0.0741 | 0.0594 |
Schistosoma mansoni | carbonic anhydrase | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0699 | 0.3502 | 0.4232 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1555 | 0.8275 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1555 | 0.8275 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1555 | 0.8275 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.