Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1573 | 0.1573 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0073 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0275 | 0.5591 | 0.5591 |
Loa Loa (eye worm) | carboxylesterase | 0.0434 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0001 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0001 | 0.0001 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0001 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0348 | 0.7611 | 0.7611 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0001 | 1 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0348 | 0.7611 | 0.7611 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0434 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0434 | 1 | 1 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0434 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0434 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0001 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0434 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0434 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0434 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0434 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0348 | 0.7611 | 0.7611 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 0.7611 | 0.7611 |
Echinococcus multilocularis | acetylcholinesterase | 0.0434 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0001 | 0.0001 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0001 | 0.0001 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0348 | 0.7611 | 0.7611 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1886 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.