Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0528 | 0.2024 | 0.2024 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1225 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.065 | 0.342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0446 | 0.1088 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.1225 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1225 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1225 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Echinococcus granulosus | cathepsin b | 0.1225 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1225 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1225 | 1 | 1 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1225 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.065 | 0.342 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.065 | 0.342 | 0.2616 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0446 | 0.1088 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.103 | 0.7775 | 0.7775 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0446 | 0.1088 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1225 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.065 | 0.342 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.103 | 0.7775 | 0.7775 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.065 | 0.342 | 0.342 |
Leishmania major | cathepsin L-like protease | 0.065 | 0.342 | 0.3079 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0827 | 0.5444 | 0.5444 |
Toxoplasma gondii | cathepsin CPL | 0.065 | 0.342 | 1 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.048 | 0.1482 | 0.1482 |
Brugia malayi | Cathepsin L-like precursor | 0.0446 | 0.1088 | 0.1088 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.065 | 0.342 | 0.342 |
Leishmania major | cathepsin L-like protease | 0.065 | 0.342 | 0.3079 |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Echinococcus multilocularis | cysteine protease | 0.065 | 0.342 | 0.342 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.048 | 0.1482 | 0.1482 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.065 | 0.342 | 0.342 |
Echinococcus multilocularis | cysteine protease | 0.065 | 0.342 | 0.342 |
Giardia lamblia | Cathepsin B precursor | 0.048 | 0.1482 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.065 | 0.342 | 0.2616 |
Brugia malayi | Papain family cysteine protease containing protein | 0.065 | 0.342 | 0.342 |
Brugia malayi | Cathepsin L-like precursor | 0.0446 | 0.1088 | 0.1088 |
Leishmania major | cathepsin L-like protease | 0.065 | 0.342 | 0.3079 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.048 | 0.1482 | 0.5 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Leishmania major | cathepsin L-like protease | 0.103 | 0.7775 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.065 | 0.342 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.065 | 0.342 | 0.342 |
Loa Loa (eye worm) | cysteine protease | 0.065 | 0.342 | 0.2616 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.048 | 0.1482 | 0.4335 |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0446 | 0.1088 | 0.1088 |
Plasmodium vivax | vivapain-2 | 0.065 | 0.342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.065 | 0.342 | 0.342 |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Leishmania major | cathepsin L-like protease | 0.065 | 0.342 | 0.3079 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.103 | 0.7775 | 0.7775 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0446 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | ctsf protein | 0.065 | 0.342 | 0.2616 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.065 | 0.342 | 0.2616 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.065 | 0.342 | 0.342 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.065 | 0.342 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.065 | 0.342 | 0.342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.065 | 0.342 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.065 | 0.342 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.065 | 0.342 | 0.342 |
Loa Loa (eye worm) | cathepsin B | 0.048 | 0.1482 | 0.0442 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Loa Loa (eye worm) | fibroinase | 0.065 | 0.342 | 0.2616 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.048 | 0.1482 | 0.1906 |
Echinococcus multilocularis | cathepsin b | 0.1225 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.065 | 0.342 | 0.342 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Leishmania major | cathepsin L-like protease | 0.065 | 0.342 | 0.3079 |
Leishmania major | cathepsin L-like protease | 0.103 | 0.7775 | 1 |
Plasmodium vivax | vivapain-2 | 0.065 | 0.342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Leishmania major | cathepsin L-like protease | 0.103 | 0.7775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0446 | 0.1088 | 0.1088 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.065 | 0.342 | 1 |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Onchocerca volvulus | 0.065 | 0.342 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.048 | 0.1482 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.103 | 0.7775 | 0.7775 |
Leishmania major | cysteine peptidase A (CPA) | 0.065 | 0.342 | 0.3079 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0446 | 0.1088 | 0.1088 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.103 | 0.7775 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.323 | Calculated partition coefficient (clogP) | ChEMBL. | 12161150 |
ED50 (functional) | = 22 mg kg-1 | Effective dose of the compound required to inhibit Staphylococcus aureus intraperitoneal (IP) infection model | ChEMBL. | 12161150 |
Log CFU (functional) | = 5.2 | Colony forming units of Staphylococcus aureus intramammary infection (IMI) model was determined at a dose of 15 mg/kg | ChEMBL. | 12161150 |
MIC (functional) | = 0.03 ug ml-1 | Minimum inhibitory concentration against Pasteurella multocida | ChEMBL. | 12161150 |
MIC (functional) | = 0.2 ug ml-1 | Minimum inhibitory concentration of the compound against Staphylococcus aureus | ChEMBL. | 12161150 |
MIC (functional) | = 0.78 ug ml-1 | Minimum inhibitory concentration against Escherichia coli | ChEMBL. | 12161150 |
MIC (functional) | = 0.78 ug ml-1 | Minimum inhibitory concentration against Escherichia coli | ChEMBL. | 12161150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.