Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | choline kinase | 0.0387 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.3433 | 1 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0387 | 1 | 1 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0038 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3433 | 0.3433 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Echinococcus granulosus | ethanolamine kinase 2 | 0.0038 | 0.0406 | 0.0406 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.3433 | 1 |
Trypanosoma brucei | choline kinase | 0.0038 | 0.0406 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0038 | 0.0406 | 0.0406 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0387 | 1 | 1 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0038 | 0.0406 | 1 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0038 | 0.0406 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Plasmodium vivax | choline kinase, putative | 0.0387 | 1 | 1 |
Schistosoma mansoni | choline kinase | 0.0038 | 0.0406 | 1 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0038 | 0.0406 | 1 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0387 | 1 | 1 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0038 | 0.0406 | 0.0406 |
Plasmodium falciparum | ethanolamine kinase | 0.0038 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | choline Kinase A | 0.0038 | 0.0406 | 0.0406 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3433 | 0.3433 |
Trypanosoma cruzi | choline kinase | 0.0038 | 0.0406 | 1 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0038 | 0.0406 | 1 |
Echinococcus multilocularis | ethanolamine kinase 2 | 0.0038 | 0.0406 | 0.0406 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0038 | 0.0406 | 0.0406 |
Brugia malayi | hypothetical protein | 0.0148 | 0.3433 | 0.3433 |
Leishmania major | choline kinase | 0.0038 | 0.0406 | 1 |
Plasmodium vivax | ethanolamine kinase, putative | 0.0038 | 0.0406 | 0.0406 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0038 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0406 | 0.0406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.