Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | angiogenesis inhibito | 0.0691 | 0.1833 | 0.1206 |
Brugia malayi | hypothetical protein | 0.0646 | 0.1596 | 0.0952 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0941 | 0.314 | 0.2641 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.0712 | 0.0712 |
Onchocerca volvulus | Matrilysin homolog | 0.1127 | 0.4116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2252 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0581 | 0.1256 | 0.0585 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0477 | 0.0712 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0711 | 0.1938 | 0.1938 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.0712 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.1079 | 0.1079 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1057 | 0.3749 | 0.8922 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0941 | 0.314 | 0.2641 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.1596 | 0.1596 |
Onchocerca volvulus | Papilin homolog | 0.0711 | 0.1938 | 0.3602 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1763 | 0.7441 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0941 | 0.314 | 1 |
Onchocerca volvulus | 0.0636 | 0.1544 | 0.2443 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0547 | 0.1079 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0581 | 0.1256 | 0.1256 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1763 | 0.7441 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0581 | 0.1256 | 0.5 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.035 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | matrixin family protein | 0.1182 | 0.4404 | 0.4404 |
Mycobacterium ulcerans | hydrolase | 0.0581 | 0.1256 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.1057 | 0.3749 | 0.3749 |
Brugia malayi | Matrixin family protein | 0.1182 | 0.4404 | 0.3975 |
Brugia malayi | ADAMTS-like protease | 0.0691 | 0.1833 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.0636 | 0.1544 | 0.4834 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0581 | 0.1256 | 0.5 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0646 | 0.1596 | 0.5003 |
Brugia malayi | Hemopexin family protein | 0.0636 | 0.1544 | 0.0895 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 25.11886432 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.