Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1408 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log PNalk | = -0.26 | Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system | ChEMBL. | 15857133 |
Log S | = 0.46 | Aqueous solubility | ChEMBL. | 10866370 |
logP (ADMET) | = -0.26 | Partition coefficient (logP) (hexane) | ChEMBL. | 3599019 |
logP (ADMET) | = 0.18 | Partition coefficient (logP) | ChEMBL. | 3882967 |
logP (ADMET) | = 0.18 | Partition coefficient (logP) | ChEMBL. | 3599019 |
logP (ADMET) | = 0.32 | Partition coefficient (logP) (carbon tetrachloride) | ChEMBL. | 3599019 |
logP (ADMET) | = 0.43 | Partition coefficient (logP) (ether) | ChEMBL. | 3599019 |
logP (ADMET) | = 0.53 | Partition coefficient (logP) (benzene) | ChEMBL. | 3599019 |
logP (ADMET) | = 1.16 | Partition coefficient (logP) (chloroform) | ChEMBL. | 3599019 |
MES (functional) | = 3.14 | Eye irritation potential accessed using Draize in vivo rabbit eye irritation test | ChEMBL. | 12672239 |
Potency (functional) | = 0.0708 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.